📄 medicine

Health System Leadership and Maternal Healthcare Service Utilisation: A Mixed-Methods Study of Rural-Urban Inequities in Anambra State, Nigeria

This mixed-methods study in Anambra State, Nigeria, reveals that while transformational leadership positively influences maternal healthcare, rural-urban inequities and structural limitations result in low overall service utilization, with only 33.1% of women accessing the full continuum of care.

Silvia Isioma Ezemenahi, Chisom Sheila Ezemenahi, Anthonia Nkechiyem Alabi, Adebayo Ramat Yusuf, Uchenna Charles Ezemena (…)2026-07-08
📄 medicine

Parental Beliefs, Vaccine Hesitancy, and Refusal Factors Toward Routine Childhood Vaccination in Sana'a City, Yemen: A Cross-Sectional Study

This cross-sectional study of 467 parents in Sana'a, Yemen, reveals that while a majority complete routine childhood vaccinations, significant hesitancy persists due to safety concerns and misinformation, highlighting the need for targeted communication strategies and healthcare worker training.

Abol Gaith¹, Nabil Ahmed, Ghaida'a Hafedh, Aisha Faisal, Ahmed Hamood Al-Shahethi2026-07-08
📄 medicine

Mortality Risk Stratification of Hospitalized Community Acquired Pneumonia Patients Can be Supported by a Three-Tier, Blood Lactate Dehydrogenase Scale. A Retrospective Analysis of 14,883 Patients

This retrospective study of 14,883 hospitalized community-acquired pneumonia patients demonstrates that a three-tier blood lactate dehydrogenase (LDH) scale effectively stratifies mortality risk, with higher LDH levels significantly correlating with increased in-hospital and 30-day mortality rates as well as longer hospital stays.

Yehonatan Marziano, Marwa Sabih, Rani Abou Arishah, Majd Koskosi, Maria Firstov, Alisa Mazur, Gad Segal, Reut Kassif-Ler (…)2026-07-08
📄 medicine

A longitudinal qualitative study of fear of cancer recurrence in patients in breast cancer remission: phenomenology, change over time, and coping strategies

This longitudinal qualitative study of 28 breast cancer survivors reveals that fear of cancer recurrence is a dynamic, highly individualized experience triggered by diverse situational factors and managed through a wide array of coping strategies, underscoring the need for personalized psycho-oncological interventions.

Jan Christopher Cwik, Marie Bollmann, Rahel Kaesmacher, Sarah Buhl, Lusine Vaganian, Sonja Bussmann, Alexander L. Gerlac (…)2026-07-08
📄 medicine

Dynamic Characteristics of Myocardial Depression After Severe Bupivacaine-Induced Local Anesthetic Systemic Toxicity: A Case Report

This case report describes a patient who survived severe bupivacaine-induced myocardial depression requiring VA-ECMO support, highlighting a unique clinical trajectory characterized by a delayed functional nadir at 24 hours followed by a reversible recovery that was effectively monitored via serial echocardiography to guide weaning.

Shujian Zhang, Bingjie Lai, Yang Hu, Fuxi Ji, Qi Yang, Yongjie Yin, Jiakun Tian, Debiao Song2026-07-08
📄 medicine

Is Anterior Reversed Proximal Humeral Locking Plate System (PHILOS) a Safe Alternative to Conventional Posterior Double Plating in Extra-Articular Distal Shaft Humeral Fractures: A Randomized Controlled Trial

This randomized controlled trial demonstrates that anterior reversed PHILOS plating is a safe and effective alternative to conventional posterior double plating for extra-articular distal humeral shaft fractures, offering comparable functional outcomes and union rates while significantly reducing operative time, surgical exposure, and the risk of nerve injury.

Sherif Hamdy Zawam, Mahmoud El-Desouky, Walid A Elnahal, Mostafa Ahmed Shawky2026-07-08
📄 medicine

An integrated single-cell transcriptomic pipeline identifies ZNF740/BRD3 and Cathepsin S as novel therapeutic targets in chronic active rim smoldering multiple sclerosis

This study presents an integrated single-cell transcriptomic pipeline that identifies ZNF740/BRD3, Cathepsin S, and DNMT1 as novel, blood-accessible therapeutic targets for treating chronic active rim smoldering multiple sclerosis through BET bromodomain inhibition, protease targeting, and epigenetic reprogramming, respectively.

John Goodman2026-07-08
📄 medicine

Prevalence and determinants of six-month virological failure among people living with HIV in Hubei, China: a population-based study

This population-based study in Hubei, China, found that the six-month virological failure rate among treatment-naïve people living with HIV was 6.8%, with female sex, higher baseline CD4 counts, and INSTI-based regimens identified as protective factors, while high baseline viral load and drug use-associated infection were significant risk factors.

Ke Hong, Dingyuan Zhao, Jie Zheng, Yurong Liu, Li Chen, Li Liu, Shixuan Qi, Qun Hu, Heng Tang, Ke Liang2026-07-08
📄 medicine

Acute Triggers and Long-Term Postpartum Outcomes of Diabetic Ketoacidosis in Pregnancy: A 7-Case Retrospective Series

This retrospective study of seven cases highlights that gestational diabetic ketoacidosis, often triggered by dexamethasone or pancreatitis, carries high fetal mortality risks and is frequently followed by persistent long-term metabolic complications, underscoring the necessity for prolonged multidisciplinary surveillance and strict glycemic management.

Ya-Li Yang, Qiao-Fang Yang, Xu-Fei Fan2026-07-08