4376 papers
This study optimizes large-scale diphtheria toxoid production by demonstrating that liquid ammonium sulfate precipitation combined with Sephadex G-75 gel filtration offers a cost-effective and efficient purification method suitable for industrial vaccine manufacturing.
In a competing risk analysis of 3,678 sepsis survivors with COPD from the MIMIC-IV database, lower albumin-corrected anion gap and congestive heart failure were identified as independent predictors of 90-day hospital readmission, with the latter's statistical significance attenuated by the high competing risk of death.
This study demonstrates that applying Kern's Six-Step framework to a resident-driven, mixed-methods needs assessment across didactic, simulation, and clinical domains successfully guided comprehensive curriculum reforms in a general surgery residency program, resulting in measurable improvements in educational quality.
This prospective validation study demonstrates that serially measured energy availability tracks the IOC REDs CAT2 severity gradient, confirming lower energy availability in athletes classified with REDs—particularly in weight-sensitive sports and males with suppressed testosterone—while noting that findings remain hypothesis-generating due to sample limitations.
This study demonstrates that a high-voltage, sinusoidally driven atmospheric pressure helium plasma jet effectively induces apoptosis and reduces viability in human bladder cancer cells, with enhanced efficacy observed in chemoresistant lines and when oxygen is supplemented to the gas flow.
This case-control study demonstrates that drug-naïve patients with obsessive–compulsive disorder exhibit significant corneal neuroinflammatory alterations, characterized by increased dendritic cell density and reduced nerve fiber parameters via corneal confocal microscopy, suggesting these noninvasive ocular biomarkers may reflect underlying neuroimmune mechanisms in the disorder.
This case report describes a rare instance of spontaneous ovarian hyperstimulation syndrome in a post-thyroidectomy patient, caused by extreme TSH levels cross-activating FSH receptors via molecular mimicry, which was successfully resolved through levothyroxine replacement and supportive care without surgical intervention.
This study demonstrates that high L1CAM expression, detected via immunohistochemistry in a cohort of 233 patients, serves as a significant prognostic biomarker for poor overall and relapse-free survival in head and neck squamous cell carcinoma (HNSCC), particularly in early-stage and node-negative cases.
Based on a 2020 survey of 1,440 elderly diabetic patients in China, this study reveals a 46.67% depression prevalence and identifies that shorter sleep duration, lower income, poor self-rated health, pain, multiple comorbidities, memory concerns, and reduced daily activity ability significantly influence depression, with sleep duration acting as a mediating factor in these relationships.
This case report describes a rare instance of concurrent Factor XI and Factor XII deficiencies with suspected diminished Factor XIII activity in a 23-year-old Bangladeshi male, highlighting the importance of systematically investigating all intrinsic pathway factors in patients with prolonged aPTT and mild bleeding symptoms.