4376 papers
This longitudinal birth cohort study found that while nearly all children were exposed to sugar within their first year and nearly half had dental caries by age 48 months, the timing or frequency of early sugar introduction was not statistically associated with caries experience at that age.
This post hoc analysis of the EAST trial found that early combined antiplatelet treatment with clopidogrel and aspirin following intravenous thrombolysis did not significantly improve 90-day functional outcomes in patients with acute minor ischemic stroke, regardless of whether they had large artery atherosclerosis or not.
This prospective study demonstrates that partial breast proton beam therapy without surgical resection is a safe and effective alternative for low-risk early-stage breast cancer, achieving five-year local control with manageable toxicity in a cohort of 11 patients.
This longitudinal study across China, the US, and the UK demonstrates that higher cardiometabolic disease burden, specific disease types like cardiovascular disease, and low socioeconomic status independently increase the risk of psychological-cognitive comorbidity in middle-aged and older adults, highlighting the need for integrated medical and socioeconomic interventions.
This machine learning study utilizing the MIMIC-IV database demonstrates that the hemoglobin-to-red cell distribution width ratio (HRR) is a superior, nonlinear predictor of type 2 diabetic kidney disease risk compared to hemoglobin or RDW alone, with an optimal risk threshold of 6.9492 identified via the LightGBM algorithm.
This prospective observational study demonstrates that serial transthoracic echocardiography can detect significant reductions in stroke volume prior to the onset of clinically apparent hypotension in women undergoing elective cesarean delivery under spinal anesthesia, establishing its potential as an early warning tool for hemodynamic monitoring.
This study demonstrates that while the Mayo Score effectively reflects disease extent in ulcerative colitis, it fails to predict the presence of premalignant colorectal lesions or extraintestinal manifestations, suggesting it measures current severity rather than long-term complications.
This study presents the first noninvasive murine model of hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer, demonstrating that external abdominal heating combined with chemotherapy significantly attenuates tumor growth, delays ascites development, and extends survival compared to normothermic treatment, thereby enabling mechanistic studies to optimize HIPEC protocols.
This study of over 22,000 Norwegian adolescents reveals that early-life multimorbidity is significantly associated with reduced health-related quality of life, particularly in mental wellbeing, with the negative impact appearing to be primarily additive based on the number of conditions rather than specific comorbidity patterns.
A 12-week supervised exercise intervention in patients with COPD significantly improved peripheral airway function as measured by impulse oscillometry and enhanced exercise capacity and symptoms, despite showing minimal changes in traditional spirometry and lung volumes.