4794 papers
This study validates the ethnomedicinal use of *Ficus thonningii* roots for treating diarrhea by demonstrating that its crude methanol extract and solvent fractions, particularly the aqueous fraction, exhibit significant dose-dependent anti-diarrheal activity in Swiss albino mice through multiple mechanisms.
This qualitative study of 23 Approved Mental Health Professionals (AMHPs) in Wales utilizes the Job Demands-Resources framework to identify systemic challenges affecting recruitment, retention, and wellbeing, ultimately proposing five key areas for improvement including shift design, supervision, interagency collaboration, infrastructure, and professional development.
This cross-sectional study of 102 nursing students in Kenyan hospitals reveals a 79.4% prevalence of workplace bullying primarily perpetrated by qualified staff, which significantly harms mental health and learning while prompting the authors to propose the Bullying-to-Attrition Cascade Framework (BACF) as a theoretical model for intervention.
The study demonstrates that the novel chalcone derivative B8HA acts as a potent dual-targeting inhibitor of histone deacetylase and tubulin, effectively suppressing triple-negative breast cancer cell proliferation, inducing apoptosis, and inhibiting metastasis and angiogenesis both in vitro and in vivo.
This case report describes a patient with sporadic Creutzfeldt-Jakob disease (CJD) who initially presented with Hashimoto's encephalopathy features and showed dramatic but transient improvement following glucocorticoid pulse therapy before rapid deterioration, ultimately confirming the CJD diagnosis through positive 14-3-3 protein and RT-QuIC assays.
This study identifies HSD11B1 as a critical driver of colorectal cancer liver metastasis that promotes invasion by activating the JNK/HSPB1 signaling axis, suggesting its potential as a prognostic biomarker and therapeutic target.
This pilot cluster-randomized trial in rural Ghana demonstrates that nine rounds of community-based mass drug administration with artemether–lumefantrine significantly reduced malaria parasite prevalence by 94% and markedly improved anaemia outcomes, particularly among children under 15 years.
This study demonstrates that a six-session Mindfulness-Based Stress Reduction (MBSR) training program significantly reduces fear of childbirth and state anxiety while improving stress coping strategies among young girls compared to a control group.
This umbrella review of 19 systematic reviews finds that while school and community-based sexual health interventions for youth aged 10–30 effectively improve knowledge, attitudes, and self-reported behaviors, they demonstrate limited impact on critical biological and clinical outcomes such as STI incidence, pregnancy rates, and viral load.
This descriptive survey conducted at an Italian tertiary cancer center reveals that while a majority of healthcare providers lack formal training in Integrative Medicine, they demonstrate a strong interest in education and maintain a positive attitude toward caring for incurable patients, highlighting an urgent need for structured educational pathways to better support patient needs.