4804 papers
The study demonstrates that the novel chalcone derivative B8HA acts as a potent dual-targeting inhibitor of histone deacetylase and tubulin, effectively suppressing triple-negative breast cancer cell proliferation, inducing apoptosis, and inhibiting metastasis and angiogenesis both in vitro and in vivo.
This case report describes a patient with sporadic Creutzfeldt-Jakob disease (CJD) who initially presented with Hashimoto's encephalopathy features and showed dramatic but transient improvement following glucocorticoid pulse therapy before rapid deterioration, ultimately confirming the CJD diagnosis through positive 14-3-3 protein and RT-QuIC assays.
This study identifies HSD11B1 as a critical driver of colorectal cancer liver metastasis that promotes invasion by activating the JNK/HSPB1 signaling axis, suggesting its potential as a prognostic biomarker and therapeutic target.
This pilot cluster-randomized trial in rural Ghana demonstrates that nine rounds of community-based mass drug administration with artemether–lumefantrine significantly reduced malaria parasite prevalence by 94% and markedly improved anaemia outcomes, particularly among children under 15 years.
This study demonstrates that a six-session Mindfulness-Based Stress Reduction (MBSR) training program significantly reduces fear of childbirth and state anxiety while improving stress coping strategies among young girls compared to a control group.
This umbrella review of 19 systematic reviews finds that while school and community-based sexual health interventions for youth aged 10–30 effectively improve knowledge, attitudes, and self-reported behaviors, they demonstrate limited impact on critical biological and clinical outcomes such as STI incidence, pregnancy rates, and viral load.
This descriptive survey conducted at an Italian tertiary cancer center reveals that while a majority of healthcare providers lack formal training in Integrative Medicine, they demonstrate a strong interest in education and maintain a positive attitude toward caring for incurable patients, highlighting an urgent need for structured educational pathways to better support patient needs.
This study demonstrates that combining the phytogenic bioenhancer piperine with amoxicillin effectively mitigates antibiotic resistance in metal-tolerant *E. coli* within broiler chickens by inhibiting efflux pumps, enhancing amoxicillin pharmacokinetics, and reducing heavy metal accumulation without compromising safety.
This retrospective cohort study demonstrates that personalized 3D printing-assisted preoperative simulation significantly improves surgical efficiency, reduces intraoperative trauma and complications, and enhances long-term functional recovery for patients with complex tibial plateau fractures compared to conventional surgery.
This case series reports that metformin rapidly improved severe fatigue and cognitive dysfunction in three women with post-COVID-19 condition or aromatase inhibitor-related symptoms, with symptom recurrence upon discontinuation and improvement upon re-initiation, suggesting a potential role for metformin in treating these syndromes linked to suspected mitochondrial dysfunction.