13396 papers
This case report describes a patient who developed malignant hyperthermia upon re-exposure to sevoflurane after a prior uneventful anesthetic and with negative genetic testing, highlighting the critical need for immediate dantrolene availability and sustained vigilance even in atypical presentations.
This longitudinal study of Chinese adults with prediabetes demonstrates that combining the metabolic score for insulin resistance (METS-IR) with four body shape indices effectively characterizes the heterogeneous trajectories of glycemic control, where higher baseline products are significantly associated with an increased risk of progressing to diabetes and a decreased likelihood of reverting to normoglycemia.
This case report describes a 33-year-old woman with FLNA-related periventricular nodular heterotopia who exhibited a comprehensive multisystem phenotype including epilepsy, cardiac, pulmonary, and ophthalmologic abnormalities, underscoring the necessity of systematic extracranial screening and multidisciplinary management for this condition.
This case report highlights the critical importance of early diagnosis for embryonal rhabdomyosarcoma in prepubertal girls by detailing a rare instance where combined vaginoscopy and pathological examination successfully identified the malignancy after initial misdiagnosis as a benign infection, thereby offering valuable clinical insights despite the study's single-case limitations.
This nationwide 45-year prospective cohort study reveals that individuals with opioid use disorder face a two-fold increased risk of lung cancer incidence and mortality compared to the general population, with elevated risks observed even among those with low smoking histories, suggesting that current screening criteria may be insufficient for this high-risk group.
This randomized controlled trial in Portugal found that while a personalized support plan did not significantly increase mean daily PAP usage over the first three months compared to standard care, it significantly improved long-term adherence rates and symptom control, suggesting potential direct and indirect annual cost savings for the healthcare system.
This study developed and validated a simplified artificial neural network model using five key clinical variables to effectively screen for Meige syndrome, demonstrating superior accuracy and calibration compared to other machine learning approaches for potential use in primary healthcare settings.
This study developed and validated a nomogram based on eight independent predictors, including age, surgery duration, and specific anesthetic agents, to effectively stratify the risk of postoperative constipation in patients undergoing fracture surgery.
This systematic review and meta-analysis of nine retrospective cohort studies suggests that metformin use, particularly long-term use of three years or more, is associated with a significantly reduced risk of gastric cancer in patients with type 2 diabetes, although further high-quality prospective studies are needed to confirm these findings due to observed heterogeneity.
This study demonstrates that while the HRR test exhibits high sensitivity and excellent agreement with the anomaloscope for classifying red-green colour vision deficiency types, its severity grades do not reliably predict D-15 test outcomes or distinguish between dichromats and anomalous trichromats.