📄 medicine

Clinical Application of Ultrasound-Guided Port Implantation via Brachiocephalic Vein and Internal Jugular Vein: study protocol for a prospective, multicenter randomized controlled trial

This prospective, multicenter randomized controlled trial aims to evaluate the efficacy, safety, and clinical outcomes of ultrasound-guided totally implantable venous access port (TIVAP) implantation via the brachiocephalic vein compared to the standard internal jugular vein approach in 640 adult oncology patients.

Ruochong Pang, Andong Yu, Wenwen Wang, Hengrui Cai, Xiaokang Sun, Liang Yin, Mingqing Zhang, Jian Zhang, Qian Yuan, Jian (…)2026-07-20
📄 medicine

Effectiveness of a Combined Depression Literacy and Group-Based Behavioural Therapy Intervention in reducing Depression-Related Stigma Among Elderly Adults in Rural India: A Quasi-Experimental Study

This quasi-experimental study demonstrates that a culturally adapted intervention combining depression literacy and group-based behavioural therapy significantly reduces personal and perceived depression-related stigma while improving mental health knowledge among elderly adults in rural India.

Sanghamitra Sahoo, Puspanjali mohapatro, Tapati Saha, Supriya Sahoo, Kabita Puhan, Pravati Tripathy2026-07-20
📄 medicine

Expression and Significance of INSM1, Syn, and CgA in Different Grades of Gastrointestinal and Pulmonary Neuroendocrine Neoplasms

This study demonstrates that while Synaptophysin serves as a broad-spectrum marker for neuroendocrine differentiation, Chromogranin A reflects tumor differentiation levels, and INSM1 effectively compensates for CgA's limitations in poorly differentiated cases, thereby validating the combined use of these three markers with Ki-67 and morphology to significantly improve the grading and differential diagnosis of gastrointestinal and pulmonary neuroendocrine neoplasms.

Xueyun Huang, Yan Zheng, Rui Wang, Ran Ning2026-07-20
📄 medicine

Interim Efficacy Analysis of Different Anticoagulant Regimens in Patients with Long-term Implantation of Inferior Vena Cava Filter

This interim analysis of patients with long-term inferior vena cava filters demonstrates that rivaroxaban anticoagulation significantly reduces deep vein thrombosis recurrence and filter thrombosis while improving clinical symptoms compared to no therapy, with extended secondary prophylaxis doses offering similar efficacy to therapeutic doses but with a lower bleeding risk.

Lei Qi, Hongzhi Sun, Yihao Wang, Huagang Li, Shuangshuang Li, Jian Zhou2026-07-20
📄 medicine

Comparison of complications of distal hypospadias repair with and without the use of postoperative prophylactic IV antibiotics: A randomized controlled trial

This randomized controlled trial involving 60 pediatric patients found that routine postoperative intravenous antibiotics did not significantly reduce overall complication rates, including surgical site and urinary tract infections, in distal hypospadias repair compared to no postoperative antibiotics.

Muhammad Rehman Waheed, Batool Fatima, Muhammad Kashif Bashir, Zuha Zafar, Babar Shahzad, Sohaib Nasir, Syed Salman Huss (…)2026-07-20
📄 medicine

Trends and Drivers of HIV/AIDS Incidence and Mortality in Mainland China (2004–2020): A Spatiotemporal and Socioeconomic Analysis

This study analyzes HIV/AIDS trends in mainland China from 2004 to 2020, revealing a significant national increase in incidence and mortality driven by sexual transmission, with pronounced spatial clustering in the Southwest, rising rates among older males and students, and education identified as the primary socioeconomic determinant.

Yunqiang Fu, Yuekun Wu, Zehao Sun, Ting Chen2026-07-20
📄 medicine

Assessment of Microbial Colonization on Used Neonatal Feeding Nipples and Infection Control Management Strategies

This study demonstrates that bacterial contamination on used neonatal feeding nipples increases with prolonged exposure time, prompting recommendations for immediate disinfection or the use of disposable equipment in hospital settings while noting that post-use disinfection may be unnecessary in family care environments.

Yu Ma, Wenting Lou, Yannan Wang, Rui Zhang, Xin An2026-07-20