3171 papers
This study reveals that outputs from wearable physical activity monitors are incompatible with current recommendations for wheelchair users with paraplegia because existing guidelines fail to distinguish between structured exercise and normal lifestyle activities, potentially leading to the erroneous conclusion that activity targets are being met when they are not.
This case report describes a rare instance of suspected warfarin-induced leukocytoclastic vasculitis in a patient with double mechanical heart valves within a resource-limited setting, demonstrating that careful clinical judgment and a strategy of temporary warfarin interruption followed by cautious dose reduction can effectively manage the skin reaction while preventing thromboembolic complications.
In older patients with symptomatic bradyarrhythmias, left bundle branch pacing demonstrated comparable procedural success to His bundle pacing but offered significantly more stable and favorable electrical lead performance over 12 months without increasing clinical complications.
This cross-sectional study of 6,129 Chinese children and adolescents reveals that a higher A Body Shape Index (ABSI), which reflects central adiposity, is independently associated with lower handgrip strength even after adjusting for BMI, with this inverse relationship being particularly pronounced in boys and older age groups.
This study identifies a TROP2-positive, stress-adapted malignant epithelial state in colorectal cancer that drives radiotherapy resistance and reveals a therapeutic vulnerability that can be exploited by combining radiation with the TROP2-targeted antibody-drug conjugate sacituzumab govitecan.
This cross-sectional study of kindergarten children in Al-Ahsa, Saudi Arabia, reveals a high prevalence of dental caries (74.1%) and inadequate preventive service utilization, finding that while caregivers' knowledge and positive attitudes improve service use, current dental visits are predominantly problem-oriented rather than preventive.
This randomized, double-blind, placebo-controlled trial demonstrates that a single low dose of esketamine (0.2 mg/kg) administered during elective cesarean section significantly improves postoperative pain control, sleep quality, and mood while reducing inflammatory markers and rescue analgesia requirements without increasing adverse events.
This cross-sectional study of 245 Indian medical trainees reveals that examinations drive the widespread use of neuroenhancing substances like coffee, energy drinks, and modafinil primarily for wakefulness and concentration, with convenience and peer influence as key drivers and prolonged use linked to significant adverse effects and dependence risks.
This retrospective cohort study at Black Lion Specialized Hospital in Ethiopia identified that older age, malignant or high-grade tumor pathology, specific tumor types, and preoperative neurological deficits are significant predictors of reduced survival among adult patients undergoing brain tumor surgery.
A national cross-sectional survey of 310 Brazilian IBD specialists reveals that the workforce is predominantly composed of academically qualified, mid-career gastroenterologists concentrated in the Southeast and South regions, highlighting significant geographic disparities that necessitate targeted strategies to expand care capacity in underserved areas.