13396 papers
This case report describes a rare instance of metachronous bilateral primary breast diffuse large B-cell lymphoma with a 15-year disease-free interval, highlighting the necessity of histopathological confirmation and the efficacy of rituximab-based immunochemotherapy followed by radiotherapy for stage IE disease.
This case-control study demonstrates that acoustic parameters extracted from naturalistic WhatsApp audio messages, particularly Formant 1, shimmer, and spectral entropy, serve as robust, non-invasive objective biomarkers for distinguishing adults with major depressive disorder from healthy controls and correlating with symptom severity.
This study characterizes a distinct molecular subgroup of differentiated high-grade thyroid carcinoma (DHGTC) driven by *DICER1* alterations, which are associated with follicular morphology, the absence of canonical MAPK drivers, and smaller tumor sizes compared to *DICER1*-wild-type cases.
This case report describes the first identification of a germline whole-gene deletion of *SDHA* in a carotid body paraganglioma using whole-genome sequencing and MLPA, demonstrating the critical necessity of these advanced methods to detect elusive structural variants that standard exome-based workflows often miss.
This case report demonstrates that a 44-year-old woman with acute intermittent porphyria and cerebellar motor dysfunction, despite normal neuroimaging and electrophysiology, achieved measurable functional improvements through a structured sensorimotor training program, suggesting that adaptive motor reorganization is possible in such cases.
This large-scale retrospective cohort study challenges the historical view of Feline Immunodeficiency Virus (FIV) as a broadly progressive systemic disease by demonstrating that, beyond a strong association with hematological issues like anemia and a moderate link to dermatological conditions, FIV seropositivity is not significantly associated with most other organ system diagnoses, suggesting that naturally acquired infection often has a milder clinical impact than previously believed.
This prospective multicentre cohort study demonstrates that early mobilisation and rehabilitation in critically ill patients, including those receiving vasopressor support, is generally safe with infrequent, transient adverse events and no statistically significant association between vasopressor use and safety incidents.
This retrospective study demonstrates that incorporating routinely obtained ocular biometric measurements, specifically anterior chamber depth and mydriatic pupil diameter, significantly improves the preoperative prediction of intraoperative floppy iris syndrome (IFIS) compared to clinical history alone.
This qualitative study applies Cassel's framework to reveal that needling-related suffering in hemodialysis patients follows a dynamic trajectory from threats to personhood through oscillating coping and unmet needs, ultimately leading to meaning reconstruction, thereby offering a stage-based roadmap for person-centered clinical interventions.
This retrospective cohort study concludes that while a three-axis burden score based on nutritional status, inflammation, and lactate clearance shows a descriptive association with in-hospital mortality in heart failure patients with atrial fibrillation within the derivation dataset, it fails to demonstrate transportable predictive value or significant incremental discrimination when validated in an external ICU cohort.