13396 papers
This study demonstrates that pre-hospital delay is a superior independent predictor of gangrenous or perforated appendicitis compared to in-hospital delay, with risk escalating nonlinearly after 24 hours of symptom onset, thereby informing clinical triage and risk stratification.
This case report describes the first instance of faecal microbiota transplantation (FMT) in a male with primary biliary cholangitis, demonstrating that the procedure successfully restored gut microbial diversity and induced sustained improvements in liver function tests without the concurrent use of ursodeoxycholic acid.
A quasi-experimental study in Eastern Uganda demonstrates that ETAT+ training and implementation significantly improved emergency clinical care documentation and reduced hospital stay duration for children under five, although no statistically significant reduction in mortality was observed.
This 22-year retrospective study of a Brazilian tertiary hospital reveals that while *Enterococcus faecalis* remains the predominant species, *Enterococcus faecium* is disproportionately linked to severe outcomes and resistance, with both species showing a concerning rise in antimicrobial resistance, particularly vancomycin resistance in *E. faecalis*, underscoring the critical need for enhanced surveillance and infection control.
This prospective study demonstrates that point-of-care ultrasound measurement of tongue thickness, with an optimal cutoff of 5.82 cm, offers superior sensitivity and comparable specificity to the Modified Mallampati Score in predicting difficult laryngoscopy.
This study demonstrates that a novel three-ratio score (TRS-3), derived from four routine laboratory measurements, significantly predicts in-hospital mortality in older critically ill patients with atherosclerotic cardiovascular disease and provides incremental prognostic value beyond standard clinical models across both MIMIC-IV and eICU cohorts.
This study developed and validated a nomogram based on seven independent risk factors—including age, systolic blood pressure, and specific biomarkers—to accurately predict in-hospital mortality in patients with acute myocardial infarction caused by left anterior descending artery occlusion.
This retrospective study of hospitalized patients with depression found that a higher frequency of as-needed (PRN) hypnotic administration during hospitalization is independently associated with an increased likelihood of being discharged on hypnotic polypharmacy, suggesting that monitoring PRN use can help identify treatment refractoriness and guide appropriate prescribing.
This cross-sectional study of 1,176 people living with HIV in Kasaï-Oriental, DRC, reveals critically low uptake and near-zero completion rates of isoniazid preventive therapy, identifying urban residence, specific antiretroviral regimens, earlier clinical stages, and active care engagement as key predictors of initiation while highlighting an urgent need to strengthen service integration and supply chains.
This retrospective study demonstrates that metagenomic next-generation sequencing (mNGS) significantly outperforms conventional culture in detecting pathogens and polymicrobial infections, offers faster turnaround times, and more effectively guides antimicrobial therapy for patients with refractory osteomyelitis.