4810 papers
This case-control study demonstrates that while elevated oxidative stress markers distinguish glioma patients from healthy controls, serum YKL-40 levels uniquely correlate with tumor grade, suggesting its potential as a biomarker for differentiating between low- and high-grade gliomas.
While bioelectrical impedance analysis (BIA) demonstrates strong correlation and consistency with dual-energy X-ray absorptiometry (DXA) for assessing body composition in Parkinson's disease, its systematic underestimation of lean mass and wide limits of agreement preclude its use as a direct substitute for DXA in individual clinical settings, though it remains valuable for population-level screening.
This randomized controlled trial demonstrates that locally applied propolis gel, when used as an adjunct to nonsurgical periodontal therapy, significantly improves clinical periodontal parameters and reduces prostaglandin E2 levels in patients with stage II grade B periodontitis compared to therapy alone.
This study demonstrates that green-synthesized silver nanoparticles derived from *Acacia ferruginea* leaf extract exhibit enhanced antioxidant and anti-hemorrhoidal efficacy in a rat model, supported by physicochemical characterization and computational evidence of interactions with TNF-α and AMPK receptors.
This prospective fMRI study of migraine patients identifies distinct default mode network connectivity patterns, particularly involving the posterior cingulate cortex and frontoparietal regions, that differentiate individuals prone to nocebo responses from those who are not, suggesting potential neurobiological markers for predicting treatment-related adverse effects.
This case report describes a rare instance of pseudotumoral rectal schistosomiasis in an Ethiopian man that closely mimicked locally advanced rectal carcinoma clinically and radiologically, underscoring the critical importance of deep biopsy and peripheral eosinophilia in endemic regions to avoid misdiagnosis and unnecessary oncologic treatment.
This study utilizes a bottom-up micro-costing approach to demonstrate that the actual hospital care costs for patients with recessive dystrophic epidermolysis bullosa (RDEB) in the UK significantly exceed current funding levels, highlighting the urgent need for accurate resource allocation and cost considerations in the development of new therapies.
This retrospective study demonstrates that a higher hemoglobin-to-red blood cell distribution width ratio (HRR) is an independent protective biomarker associated with a reduced risk of central retinal vein occlusion and predicts better visual outcomes following anti-VEGF therapy.
This study demonstrates that protocatechuic aldehyde ameliorates high-fat diet-induced hepatic cholesterol dysregulation in rats by upregulating LDLR, LXRα, and CYP7A1 while downregulating PCSK9, thereby enhancing LDL uptake and bile acid synthesis to reduce lipid accumulation and atherosclerotic risk.
This study of nearly 10,000 Chinese adults over 45 reveals that adverse childhood experiences are significantly associated with depressive symptoms in later life, a relationship that is partially mediated by sleep duration.