📄 Category

medicine

4814 papers

📄 medicine

Development and Internal Validation of a Nomogram for Predicting One-Year All-Cause Mortality in Heart Failure Patients Undergoing Non-Cardiac Surgery: A Retrospective Analysis of 308 Cases

This study developed and internally validated a high-accuracy nomogram based on six independent clinical variables to effectively predict one-year all-cause mortality in heart failure patients undergoing non-cardiac surgery, demonstrating superior performance compared to the conventional Revised Cardiac Risk Index.

Yunhui Zhang, Enyao Qi, Yan Zhou, Fengqin Jiang, Peng Wang2026-07-07
📄 medicine

Endpoint Genotyping of A2063G and A2064G Mutations in Mycoplasma pneumoniae

This study developed and validated a highly sensitive and specific fluorescence-based endpoint genotyping assay using minor groove binding probes to rapidly and accurately detect the A2063G and A2064G macrolide resistance mutations in *Mycoplasma pneumoniae*, demonstrating perfect agreement with commercial standards in clinical samples.

Hyeonseek Park, Minhee Kang, Sun Ae Yun, Tae Yeul Kim, Hee Jae Huh2026-07-07
📄 medicine

Nrf2/HO-1 Signaling Axis Activation Underpins the Endogenous "Rest-Relief" Mechanism in a Rat Model of Lumbar Spinal Stenosis-Induced Neurogenic Intermittent Claudication

This study demonstrates that in a rat model of lumbar spinal stenosis, the endogenous relief of neurogenic intermittent claudication during rest is driven by the activation of the Nrf2/HO-1 signaling axis, which mitigates oxidative stress and neuroinflammation caused by cyclic ischemia-reperfusion, suggesting this pathway as a promising target for non-surgical therapeutic interventions.

Daiyuan Liu, Haibao Wen, Minrui Fu, Jinghua Gao, Chunyu Gao, Luguang Li, Jianguo Li, Minshan Feng, Wu Sun2026-07-07
📄 medicine

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

This study demonstrates that co-administration of imperatorin or isoimperatorin significantly alters the pharmacokinetics of the breast cancer drug abemaciclib in rats by inhibiting its metabolism, likely through competition for CYP3A4 binding, suggesting a need for clinical caution when combining these agents.

Chengfeng Wang, Jianfeng Wang, Zebei Lu, Yu Wang, Abdullah Al Mamun, Md Siddiqul Islam, Shuanghu Wang, Yunfang Zhou, Min (…)2026-07-07
📄 medicine

Impact of non-invasive ventilation on lung hyperinflation: A physiological study using electrical impedance tomography in COPD patients

This prospective physiological study of 30 stable COPD patients demonstrates that non-invasive ventilation can induce a reduction in lung volume, which is associated with improved sleep quality and a more pronounced reduction in dyspnea.

Alexandre Garcia, Carole Decloedt, Pierre Schilfarth, Marina Guecamburu, Arthur Pavot, Arnaud Maurac, Benjamin Repusseau (…)2026-07-07
📄 medicine

Beyond the pandemic declaration: Persistent daily health complaints in diabetic COVID-19 survivors and the protective effect of prior vaccination in Indonesian primary care

This cross-sectional study of 420 diabetic COVID-19 survivors in Indonesian primary care reveals that pre-infection vaccination is associated with a 45% reduction in persistent daily health complaints, highlighting the importance of integrating vaccination promotion into chronic disease management in low- and middle-income countries.

Putri Bungsu Machmud, Husnul Khatimah, Renti Mahkota, Jessica Veronica, Arie Wahyu Wijayanto2026-07-07
📄 medicine

Multimodal imaging features of intra-parenchymal schwannoma

This retrospective study of 22 intra-parenchymal schwannoma cases characterizes the condition's distinct multimodal imaging profile, which includes well-circumscribed solid-cystic masses with significant edema, heterogeneous contrast enhancement, high perfusion, unrestricted diffusion, and specific MRS metabolic patterns, to aid in their accurate diagnosis.

Jiaying Gong, Zelan Ma, Yan Deng, Qianwen Guan, Zhongwen Zhou, Shukun Liao, Ke Sun, Na Shen, Donghui Gan, Hanqiu Liu2026-07-07
📄 medicine

Surrogate Decision-Making Confidence Across Acute and General Scenarios: Predictors and Ethical Reasoning in a Mixed-Methods Study

This mixed-methods study reveals that surrogate decision-makers report significantly lower confidence in acute scenarios compared to general ones, with self-efficacy emerging as the strongest predictor of confidence across both contexts, suggesting that targeted preparation to boost self-efficacy could improve decision-making readiness.

Yuxin Zhao, Onyinye Mbanefo, Sean Lawrence, Nethra Rajeshkumar, Emily Jon, Benjamin Katz, Pamela Teaster2026-07-07
📄 medicine

Post-operative Pain of Endoscopic versus Mini-open Carpal Tunnel Release: A Randomized Controlled Trial

This Level I randomized controlled trial demonstrates that while both endoscopic and mini-open carpal tunnel release are equally safe and effective for long-term outcomes, the endoscopic approach offers superior early pain reduction and faster return to work without increasing complication risks.

Patarpon Inthawong, Woraphon Jaroenporn, Korntanat Thongvinij, Thanapol Wangrattanapranee, Lertkong Nitiwarangkul, Wisar (…)2026-07-07