Heated Tobacco Products cause Pulmonary Injury and Inflammation: Rapid Elevation of Extracellular Vesicles Expressing ACE, C3, P4HB and CC16 in Healthy Young Individuals
This randomized crossover study demonstrates that acute inhalation of heated tobacco products by healthy young individuals rapidly elevates circulating extracellular vesicles expressing biomarkers associated with pulmonary injury, cellular stress, and inflammation, suggesting these products may impair lung health and trigger pro-thrombotic cascades.