📄 medicine

Heated Tobacco Products cause Pulmonary Injury and Inflammation: Rapid Elevation of Extracellular Vesicles Expressing ACE, C3, P4HB and CC16 in Healthy Young Individuals

This randomized crossover study demonstrates that acute inhalation of heated tobacco products by healthy young individuals rapidly elevates circulating extracellular vesicles expressing biomarkers associated with pulmonary injury, cellular stress, and inflammation, suggesting these products may impair lung health and trigger pro-thrombotic cascades.

Georgy Melnikov, Gustaf Lyytinen, Anders Blomberg, Jenny Bosson, Linnea Hedman, Fariborz Mobarrez, Magnus Lundbäck, Luka (…)2026-07-06
📄 medicine

Prevalence of Significant Coronary Artery Disease in Patients with Severe Aortic Stenosis and the Diagnostic Value of the Coronary Calcium Score and Echocardiographic Parameters: A Cohort Study at a Referral Center in the Ecuadorian Andean Highlands

This retrospective cohort study of 390 patients with severe aortic stenosis in the Ecuadorian Andean Highlands found a 12.1% prevalence of significant coronary artery disease, identifying the coronary calcium score as the most effective noninvasive diagnostic tool and the low-flow/low-gradient echocardiographic pattern as the strongest phenotypic predictor, while noting that the local prevalence is lower than in European and North American registries.

Jonathan David Melena Zapata, María Belén Mena Ayala, María Sol Calero Revelo, Gabriela Carolina Santamaría Naranjo, Lau (…)2026-07-06
📄 medicine

Developing and Validating a Tool to Assess Orthodontists' Awareness and Clinical Use of Maxillary Molar Distalization

This study developed and validated a 15-item electronic questionnaire to assess orthodontists' awareness and clinical practices regarding maxillary molar distalization, revealing that most practitioners utilize the technique primarily for Class II malocclusions with a preference for skeletally anchored devices while emphasizing the critical role of three-dimensional imaging to prevent bone damage.

Mostafa Sofar, Mushriq Abid, Kerolos AlHakeem, David Bearn2026-07-06
📄 medicine

Prophylactic Post-Lung Transplant Bacteriophage Therapy against XDR Pseudomonas aeruginosa in Cystic Fibrosis: a case report

This case report describes the first use of personalized prophylactic bacteriophage therapy to successfully suppress extensively drug-resistant Pseudomonas aeruginosa in a cystic fibrosis patient following lung retransplantation, although the patient ultimately died from unrelated multiorgan failure.

Jules Milesi, Sophie Alexandra Baron, Carole Eldin, Fanny Mathias, Florence Peyron, Katlyn Jumel, Alexandre Bleibtreu, G (…)2026-07-06
📄 medicine

Occupational exposure limit compliance may underestimate health risks in silica dust exposed workplaces

This study of workplaces in Chongqing, China, reveals that relying solely on occupational exposure limit compliance significantly underestimates health risks from silica dust, as nearly 40% of compliant positions were still classified as high or very high risk by semi-quantitative assessment, suggesting that combining both methods is essential for effective silicosis prevention.

Maojia Wang, Heng Diao, Junyi Wang, Yuhong Lei, Hong Yao2026-07-06
📄 medicine

Preparedness for 3D Bioprinting Among Healthcare Professionals: A Cross-Sectional Study of Awareness, Knowledge, and Attitudes in South India

This cross-sectional study of healthcare professionals in South India reveals moderate awareness and highly positive attitudes toward 3D bioprinting, despite a significant lack of formal educational exposure, suggesting an urgent need for educational initiatives to facilitate the technology's future adoption.

Sreenandini Nandakumar, Vijayalakshmi Gaddam, Aneeta E. Samuel, Anjum John2026-07-06
📄 medicine

Maternal knowledge of low birth weight and its predictors among Rohingya women of reproductive age in the Forcibly Displaced Myanmar Nationals (FDMN) camps in Bangladesh

This cross-sectional study of 300 Rohingya women in Bangladesh's FDMN camps reveals alarmingly low maternal knowledge of low birth weight, identifying maternal and household-head education as the strongest independent predictors and underscoring the urgent need for targeted, culturally adapted health education within humanitarian responses.

Maliha Jebin, Abu Ansar Md Riz, A B M Alauddin Chowdhury2026-07-06
📄 medicine

Insulin resistance and glucose-metabolic changes in patients with sepsis during hospitalization and recovery: a prospective observational study

This prospective observational study of non-diabetic sepsis patients reveals that glucose-metabolic responses during hospitalization and recovery are characterized by substantial inter-individual heterogeneity rather than a consistent pattern of transient insulin resistance.

Tania Aabolt Mols Poulsen, Sarah Bøndergaard Duncan, Mahsa Jalili, Peter Haulund Gæde, Jens Rikardt Andersen2026-07-06
📄 medicine

The Impact of Late Diagnosis on Health Outcomes Among Women and Children in Low-Income Communities in Northern Nigeria: A Quantitative Feasibility Study

This quantitative feasibility study in Borno State, Nigeria, reveals that late diagnosis of treatable conditions affects nearly 95% of women and children, driven by socioeconomic and health system barriers, and is significantly associated with severe clinical complications, prolonged hospitalization, and doubled medical costs.

Imose Itua, Emmanuel Njadvara2026-07-06