📄 medicine

Exhaled endogenous pulmonary nitric oxide in intubated and ventilated patients with acute respiratory distress syndrome

This pilot study utilized a prototype Optical Feedback Cavity-Enhanced Absorption Spectroscopy (OFCEAS) analyzer to demonstrate that, contrary to previous indications, fractional exhaled nitric oxide (FeNO) levels do not significantly differ between intubated patients with acute respiratory distress syndrome (ARDS) and control patients, while successfully establishing the feasibility of continuous, cycle-resolved FeNO monitoring in mechanically ventilated individuals.

Raphaël Briot, Nicolas Laubriat, Thibault Frappier, Nicolas Favre-Petit-Mermet, Myriam Casez-Brasseur, Florian Sigaud, M (…)2026-07-06
📄 medicine

Quality and Content of Abdominal Aortic Aneurysm-Related Short Videos on TikTok, Bilibili, and YouTube: A Cross-Platform Content Analysis

This cross-platform content analysis reveals that while YouTube and medically affiliated sources offer higher-quality abdominal aortic aneurysm (AAA) videos than TikTok and Bilibili, all platforms suffer from significant gaps in clinically relevant information and a disconnect between user engagement and content reliability, highlighting an urgent need for standardized, medically authored content and improved platform governance.

ming wang, chenghao yang, min zhou, zhenyu shi2026-07-06
📄 medicine

Sustained optogenetic expression in skeletal muscle is limited by host adaptive immunity, but preserved with targeted immunosuppression

This study demonstrates that while host adaptive immunity limits sustained optogenetic expression in skeletal muscle for treating obstructive sleep apnea, a combination of rapamycin and cyclosporin effectively mitigates this immune response to preserve durable transgene expression and functional muscle activation.

Fiona L. Knapman, Elena Shklovskaya, Ryan Swain, Anita Turner, Nigel H. Lovell, Leszek Lisowski, Peter A. Cistulli, Pete (…)2026-07-06
📄 medicine

Intelligent Pneumoperitoneum System Stabilizes Hemodynamics in Robotic Pheochromocytoma Resection: A Retrospective Cohort Study

This retrospective cohort study demonstrates that the intelligent pneumoperitoneum system (Zhonghe Third-Generation) significantly improves hemodynamic stability, reduces vasopressor requirements, and shortens operative time in robotic pheochromocytoma resection compared to conventional methods.

Yuchen Bai, Xuanhan Hu, Dechao Feng, Dahong Zhang, Qijun Wo2026-07-06
📄 medicine

H2O2- and Light-Triggered MnO2-Based Nanoswitches for Microenvironment Reprogramming and Photodynamic Therapy of Hypoxic Atherosclerotic Plaques

This study presents a stimulus-responsive MnO2-based nanoswitch that utilizes intraplaque H2O2 to simultaneously generate oxygen, reprogram pro-inflammatory macrophages, and activate photodynamic therapy, thereby effectively treating hypoxic atherosclerotic plaques while minimizing off-target toxicity.

Yong Geun Lim, Jin Hyuk Kim, Ryeong Hyun Kim, Hongki Yoo, Jin Won Kim, Kyeongsoon Park2026-07-06
📄 medicine

Immune Checkpoint Response Profiles and Resistance Mechanisms in NSCLC Revealed by Circulating Extracellular Vesicle Proteomics

This study utilizes high-plex proteomic profiling of circulating extracellular vesicles from NSCLC patients to identify a six-protein signature that predicts immune checkpoint inhibitor resistance and reveals distinct immune evasion mechanisms associated with poor treatment outcomes.

Catherine Taylor, Michelle Davey, Eric P. Allain, Ammar Sabir Cheema, Nicolas Crapoulet, Nicholas Finn, Mahmoud Abdelsal (…)2026-07-06
📄 medicine

Global Research Landscape of Benign Prostatic Hyperplasia (2010–2026): A Bibliometric and Visualized Analysis Revealing Evolving Trends, Hotspots, and Future Frontiers

This bibliometric analysis of 5,463 publications from 2010 to 2026 maps the global Benign Prostatic Hyperplasia research landscape, revealing China's dominance in output, the United States' leadership in collaboration, and a significant paradigm shift from traditional surgical interventions toward inflammation-driven mechanisms and minimally invasive therapies.

Qinghua Xie, Qingzhi Ran, Xuan Yang, Danping Fan, Xinrong Fan2026-07-06
📄 medicine

Lateral Violence and Its Relationship with Personality traits Among Emergency Department Nurses at Ardabil Medical Training Centers (2024)

This 2024 cross-sectional study of 243 emergency department nurses in Ardabil, Iran, reveals that lateral violence is highly prevalent and significantly correlated with specific personality traits, particularly noting that higher neuroticism and lower extraversion are associated with increased exposure to and underreporting of workplace aggression.

Mansoreh Karimollahi, Masomeh Aghamohammadi, Farideh SHahrivar2026-07-06
📄 medicine

Absence of a Weekend Effect on In-Hospital Mortality in Upper Gastrointestinal Bleeding: A Multisite Study from an Integrated Health System

In a large retrospective study of over 7,600 patients within an integrated health system, weekend admission for upper gastrointestinal bleeding was not associated with increased in-hospital mortality or other adverse outcomes, suggesting that standardized 24/7 care pathways effectively eliminate the "weekend effect" in this condition.

Ali Sohail, Uday Sankar Akash Vankayala, Bivin George, Jon Javor, Liliane Deeb2026-07-06