13396 papers
This comprehensive review examines Alagille Syndrome, a rare autosomal dominant disorder caused by JAG1 or NOTCH2 mutations, by detailing its highly variable multisystem clinical manifestations, underlying Notch pathway pathogenesis, and evolving management strategies ranging from multidisciplinary care to emerging targeted therapies.
This retrospective study establishes trimester-specific thyroid reference intervals for singleton and twin pregnancies, revealing significant gestational-stage-dependent differences in hormone profiles that underscore the need for pregnancy-type-specific standards to improve the diagnosis of thyroid dysfunction.
This cross-sectional study of 733 community-dwelling older adults in Tianjin, China, found that higher cardiovascular risk burden, as measured by the China-PAR score, is significantly associated with lower global and domain-specific cognitive performance.
This study reveals that hematology-oncology fellows in the United States exhibit significant geographic mobility favoring higher-income and less racially diverse regions, a trend that exacerbates cancer care disparities but may be mitigated by targeted interventions at the fellowship-to-practice transition.
This case report demonstrates that real-time FloTrac®-guided haemodynamic monitoring, by precisely tracking stroke volume variation, systemic vascular resistance index, and cardiac index, enabled successful goal-directed fluid and vasopressor resuscitation for a patient experiencing profound cefuroxime-induced anaphylactic shock following anaesthesia induction.
This case report describes a patient with end-stage cirrhosis and massive ascites who achieved complete resolution of symptoms and sustained 24-year survival following treatment with combined Chinese-Western medicine, supporting the concept of hepatic recompensation.
This study utilized a modified two-round Delphi technique involving a panel of experts to validate and establish a curriculum of 42 core competencies for enhancing dermatology and venereology education among undergraduate medical students in Burundi.
This longitudinal study of 1,622 Chinese university students reveals three distinct depressive symptom trajectories and uncovers a paradoxical mechanism where higher social capital indirectly exacerbates depression by reducing sports participation, highlighting the need for balanced mental health interventions.
This study validates a quantitative 3D human BBB organoid model using UPLC-MS/MS, demonstrating that its drug uptake ratios significantly correlate with in vivo brain-to-plasma ratios and outperform current in silico prediction tools for assessing blood-brain barrier permeability.
A quasi-experimental study in Nairobi's informal settlements demonstrates that a context-specific on-site education and support supervision intervention significantly improved street food vendors' food safety attitudes and practices, despite not yielding a significant change in knowledge.