📄 Category

medicine

13396 papers

🧬 biology

Transcriptomics-based drug repositioning in a neurocysticercosis rat model identifies putative therapeutic candidates reported to mitigate neuroinflammation and neurodegeneration

Using transcriptomic profiling of a rat model to analyze molecular changes during neurocysticercosis infection and treatment, researchers identified 30 candidate drugs for repurposing, including five known to mitigate neuroinflammation and neurodegeneration, thereby establishing a molecular rationale for new therapeutic strategies against this disease.

Omar Melo, Oksana Huerta, Karla Villalobos, Nancy Chile, Sneider A. Gutierrez Guarnizo, Hugo Naya, Cesar M. Gavidia, Hec (…)2026-10-21
📄 medicine

Frequency and factors associated with the offering of gifts or favors in access to health care in Guinea: a cross-sectional study based on Afrobarometer 2022 data

Based on 2022 Afrobarometer data, a cross-sectional study in Guinea reveals that over one-third of public health facility users offer gifts or favors to access care, a practice primarily driven by perceived difficulties in accessing services, food insecurity, and a lack of respect from staff rather than individual demographic characteristics.

Daniel Vongbo Traore, Almamy Amara Toure, Abdoulaye Fode Toure, Houssainatou Bah, Mohamed Prince Kaba2026-10-21
🧬 biology

Integrated multi-omics and experimental analyses identify three post-translational modification genes driving osteosarcoma progression and prognosis

This study integrates multi-omics analysis and experimental validation to identify three post-translational modification-related genes (VCAN, RRP12, and CREG1) as key drivers of osteosarcoma progression, establishing a robust prognostic model and highlighting CREG1 as a potential therapeutic target.

Yang Su, Ji'an Liu, Zhengrui Li, Zhu Liu2026-10-21
📄 medicine

Brief Communication: Oral pre-exposure prophylaxis history and willingness to use injectable HIV prevention among clients at two Ugandan clinics

This study of 116 clients at two Ugandan clinics found that willingness to use injectable HIV pre-exposure prophylaxis was highest among current oral users (81.8%) compared to former (42.4%) and never users (50.0%), highlighting the need to assess information needs across different oral-use histories and verify if stated willingness translates to actual initiation.

Stephen Charles Olet, Wandera Uthmaan Muluga, Drake Musoki, Bernard Raymond Kihumuro, Muluga Farid, Ivan Ssebandeke, Fio (…)2026-10-21
📄 medicine

Stable chronic hemodialysis porcine model via renal vein catheterization of the posterior vena cava

This study establishes a stable chronic hemodialysis porcine model using Göttingen and NIBS miniature pigs, demonstrating that heavier animals with catheters inserted into the posterior vena cava via the right renal vein offer superior survival and fewer complications compared to those with jugular-venous access.

Toshimasa Nakao, Yoshitaka Iwazu, Hideyuki Mukai, Yasunobu Hasuta, Kazuhiro Endo, Takehiro Ohyama, Sho Nishida, Kyoko Mi (…)2026-10-21
📄 medicine

Benzoxazolone and Hydrazone Hybrids: Synthesis, Characterization, Biological Evaluation in Breast Cancer and In Silico Studies

This study reports the synthesis, characterization, and biological evaluation of a novel series of benzoxazolone-hydrazone hybrids, identifying specific derivatives (notably compound 14) as potent dual inhibitors of aromatase and monoamine oxidase enzymes with promising antiproliferative activity against breast cancer cells and favorable drug-likeness profiles.

Hayrünnisa Taşci, Begüm Nurpelin Sağlık Özkan, Abdullah Burak Karaduman, Birsen Tozkoparan, Nesrin Gökhan Kelekçi2026-10-21
📄 medicine

Selective uptake of medicines outside China's National Reimbursement Drug List by commercial specialty-drug rosters: a multi-product audit of the 2020–2025 negotiation cohorts

This multi-product audit reveals that while China's commercial specialty-drug rosters selectively cover approximately 12.8% of medicines excluded from the National Reimbursement Drug List, this uptake is heavily concentrated among high-cost, high-innovation antineoplastic therapies and varies significantly by application history and commercial track.

Yuehua Liu, Yuzhe Zhang, Yongliang Mu, Yulong Li, Yuanhao Wan, Jian Wang2026-10-21
📄 medicine

Real-world outcomes after rituximab and abatacept initiation in rheumatoid arthritis: a retrospective single-centre cohort study

This retrospective single-centre study describes the clinical outcomes and safety of rituximab and abatacept initiation in routine rheumatoid arthritis care, finding significant reductions in disease activity for patients with evaluable paired data while emphasizing that the limited and incomplete longitudinal data preclude definitive conclusions regarding comparative effectiveness or causality.

Özgür Özçelik¹, Sedat Kiraz²2026-10-21
📄 medicine

Effectiveness of AI-Driven Digital Mental Health Interventions and Their Implications for Health Service Delivery: A Systematic Review and Meta-Analysis (2013–2025)

This systematic review and meta-analysis of 385 studies from 2013 to 2025 demonstrates that AI-driven digital mental health interventions significantly improve symptoms of depression, anxiety, and mood disorders, yet their large-scale integration into health systems requires further research on validation, equity, implementation, and governance.

Mochamad Nursalim¹, Wulan Patria Saroinsong¹, Susan Ledger³, Sherrin Nurlita Widya²2026-10-21
📄 medicine

SRGN aggravates cerebral ischemia/reperfusion injury by inducing SLC7A11 depletion and excessive mitophagy-dependent neuronal death

This study demonstrates that Serglycin (SRGN) exacerbates cerebral ischemia/reperfusion injury by promoting SLC7A11 degradation and excessive mitophagy, identifying circulating SRGN as a potential biomarker and RBC-EVs@siSRGN as an effective targeted therapeutic strategy for ischemic stroke.

Donglin Hao, Bona Wu, Fuji Yang, Xueling Jiang, Yongmin Yan, jing zhou2026-10-21