13396 papers
This study identifies CD38 as a critical mediator linking donor aging and ischemic stress to cellular senescence and ischemia-reperfusion injury in donor lungs, demonstrating that its inhibition preserves NAD⁺ levels, attenuates inflammatory damage, and improves graft outcomes.
This study utilizes counterfactual modeling to demonstrate that even a one- or two-year delay in Brazil's 1996 introduction of universal antiretroviral therapy would have resulted in tens of thousands of additional HIV/AIDS deaths by 2023, highlighting the critical importance of maintaining uninterrupted public health interventions.
A study of Cameroonian women reveals a high prevalence of diverse high-risk HPV genotypes, including several non-vaccine types like HPV39, 59, and 66, suggesting that current vaccine coverage may be insufficient and highlighting the need for broader-valence vaccines alongside enhanced screening programs.
This study reveals that intratumoral Influenza A virus infection drives platinum resistance and invasive reprogramming in non-small cell lung cancer by activating a specific drug metabolism program via NLRP3 inflammasome signaling, ultimately leading to poor clinical outcomes.
This uncontrolled case report describes a patient with IDH-wildtype glioblastoma who experienced a 45-month overall survival and a transient period of functional and radiological improvement following exposure to a mixed cannabinoid-terpenoid regimen, though the study explicitly notes that treatment causality and tumor response remain unverified due to the lack of controlled methodology.
This study identifies ABCB1-mediated drug efflux as a key mechanism of resistance to VpreB1-targeted antibody-drug conjugates in B-cell acute lymphoblastic leukemia and demonstrates that this resistance can be overcome either by inhibiting ABCB1 or by utilizing non-ABCB1 substrate payloads.
This paper proposes a comprehensive, multidisciplinary support model—including 24-hour counseling, shelter, grief care, and volunteer foster care—to address the psychological distress and bonding challenges faced by parents of children with disabilities, ultimately advocating for an inclusive society where every child is loved and cared for.
This cross-sectional study of 300 type 2 diabetes outpatients in Zambia reveals a high prevalence (70%) of medication reconciliation errors, which are significantly driven by comorbidity burden, fragmented care across multiple specialty clinics, and cost-related non-adherence.
This single-center pilot study demonstrates that a calcium-free predilution strategy is a feasible rescue approach for maintaining circuit patency during continuous renal replacement therapy in critically ill patients with high bleeding risks when standard anticoagulation cannot be utilized, achieving acceptable filter longevity without causing uncontrolled metabolic complications.
This five-year retrospective study at Yekatit 12 Hospital in Addis Ababa found that the incidence of active tuberculosis among HIV-positive patients on second-line ART was 1.13 per 100 person-years, with advanced clinical stage, poor ART adherence, and undernutrition identified as significant predictors.