📄 Category

medicine

5683 papers

📄 medicine

Multidimensional Mechanistic Elucidation of Panax Notoginseng Saponins for Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation

This study elucidates the therapeutic mechanism of Panax Notoginseng Saponins (PNS) against alcohol-induced osteonecrosis of the femoral head by integrating network pharmacology, molecular dynamics simulations, and in vivo validation to demonstrate that PNS ameliorates the condition through a multi-component, multi-target approach primarily involving the inhibition of osteocyte apoptosis and modulation of the VEGF signaling pathway.

Ruokun Bai, Hua Su, Jian Mo, Xiaoyun Zhang, Zhengpeng Li, Xiangshan Chen, Sentao Ye, Xiayu Nie, Shuai Chen2026-07-02
📄 medicine

Reliability and Validation of a Visual Scale for Assessing Mucosal Healing After Third Molar Extraction

This study presents and validates a digital visual scale for assessing mucosal healing after third molar extraction, demonstrating that while the tool achieves high consensus for advanced healing stages and is widely accepted by dental professionals for standardizing postoperative evaluation, its inter-rater reliability remains fair and requires further refinement for intermediate healing stages.

Julia Gomes Lucio de Araujo, Beatriz Campos Pereira, Lais Albuquerque Fernandes, Natacha Kalline de Oliveira, Luciana Co (…)2026-07-02
📄 medicine

Maternal Secondhand Smoke Exposure and Risk of Preterm Birth: A Systematic Review and Meta-Analysis With National Epidemiological Context From Indonesia

This systematic review and meta-analysis demonstrates that maternal secondhand smoke exposure significantly increases the risk of preterm birth (pooled OR = 1.63), a finding contextualized by high indoor smoking rates in Indonesia that underscores the urgent need for comprehensive tobacco control measures to protect maternal and neonatal health.

Belva Bhadranitya Buana, Ario Danianto, Roro Cahyowati, Gatot Dwi, Dayinta Liris Kawuryan2026-07-02
📄 medicine

MicroRNAs detect breast cancer in nipple aspirate fluid: results from a Dutch multicenter cross-sectional study

This Dutch multicenter study demonstrates that a 20-miRNA panel analyzed in nipple aspirate fluid can effectively discriminate between breast cancer patients and healthy controls with an AUC of 0.70, suggesting its potential as a non-invasive tool for personalized screening, particularly for women with dense breasts.

Laura A. de Rooij, Susana I.S. Patuleia, Bas B.L. Penning de Vries, Sjoerd G. Elias, Joost M. H. H. van Gorp, Julia E.C. (…)2026-07-02
📄 medicine

Factors Associated with the Cholera Epidemic in the Rural Health Zone of Shabunda, South Kivu, Democratic Republic of the Congo: A Matched Case-control Study

This matched case-control study in Shabunda, DRC, identifies that the severe cholera epidemic is driven by a convergence of environmental, socio-economic, and behavioral factors—specifically lack of water treatment, absence of handwashing kits, mining-related visitor exposure, and riverine proximity—which create a dose-response risk relationship necessitating urgent multi-sectoral WASH interventions.

KISULU KINYEMA Gaston, RIZIKI IDANGI Monique2026-07-02✓ Author reviewed ⓘ
📄 medicine

Risk factors and nomogram prediction model for recurrence after CO2 laser treatment in women with condyloma acuminatum

This study identified independent risk factors for condyloma acuminatum recurrence in women following CO2 laser treatment—including sexually transmitted infections, immunosuppressant use, diabetes, hybrid HPV infection, multifocal lesions, and anxiety levels—and developed a validated nomogram model with high predictive accuracy to estimate relapse risk.

Chunchun Zou, Jingmin Yu, Yan Chen2026-07-02