📄 Category

medicine

5683 papers

📄 medicine

Associations between substance use and oppositional defiant disorder among U.S. adolescents: A national study of high-prevalence subgroups

This national study of over 226,000 U.S. adolescents found that cannabis use has the strongest association with oppositional defiant disorder (ODD), while machine learning analysis identified male adolescents aged 12–17 who use alcohol but not cannabis as the subgroup with the highest predicted probability of ODD, supporting the need for targeted screening in school settings.

Md Roungu Ahmmad, Xiaoli Zhang, Ukamaka Oruche2026-07-02
📄 medicine

Risk Factors for Pharyngocutaneous Fistula After Total Laryngectomy: An 11-year Retropective Cohort Study in Burkina Faso

This 11-year retrospective cohort study conducted in Burkina Faso identifies surgical site infection, advanced age, postoperative anemia, malnutrition, and prolonged operative time as significant risk factors for pharyngocutaneous fistula following total laryngectomy, highlighting the need for targeted preventive measures in sub-Saharan settings.

Adama YAMEOGO, Aboubacar Goueta, Yvette Gyebre2026-07-02
📄 medicine

Sexual identity as a moderator of associations between lifetime MDMA/ecstasy or psilocybin use and mental health outcomes: An exploratory analysis of a nationally representative sample using NSDUH 2015–2019

This exploratory analysis of nationally representative data found little evidence that sexual identity moderates the associations between lifetime MDMA or psilocybin use and mental health outcomes, with only non-significant-after-correction signals suggesting potential differences in how psilocybin relates to depression for heterosexual versus bisexual individuals.

Maya Seale2026-07-02
📄 medicine

Exposome-wide Association Patterns across Cardiovascular Disease Outcomes: Findings from the NHANES

This cross-sectional exposome-wide association study of 56,253 NHANES participants reveals that cardiovascular outcomes, particularly composite CVD and heart failure, exhibit distinct yet reproducible environmental exposure signatures, with blood cadmium and serum cotinine emerging as key risk factors across multiple disease endpoints.

Hao Wang, Yulu Zheng, Jian Geng, Zhiyuan Wu, Yahong Zhu, Ziqi Zhou, Hang Qu, Lois Balmer, Aimin Yang, Xingang Li, Zheng (…)2026-07-02
📄 medicine

Associations of cumulative exposure and dynamic trajectories of the Modified Life’s Essential 8 with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS)

This longitudinal study of Chinese adults demonstrates that higher baseline and cumulative Modified Life's Essential 8 (mLE8) scores, as well as sustained high mLE8 trajectories over time, are significantly associated with a reduced risk of developing incident cardiometabolic multimorbidity.

Wuhao Li, Zhengwen Xu, Zhehui Yin, Xiaojie Xie2026-07-02
📄 medicine

Health-related quality of life and its clinical and psychosocial correlates among men entering an in-prison substance-use rehabilitation programme in Indonesia: a cross-sectional study

This cross-sectional study of men entering an Indonesian in-prison substance-use rehabilitation program reveals that their health-related quality of life is substantially impaired and primarily associated with anxiety and marital status rather than the type of substance used, highlighting the need for integrated mental health screening in correctional settings.

Zikri Aulio Septiawan, Berlian Isnia Fitrasanti, Shelly Iskandar2026-07-02
📄 medicine

An Intervention Study Protocol on Reducing Polycyclic Aromatic Hydrocarbons (PAHs) via Nutritional Supplementation in Women of Reproductive Age

This study protocol outlines an 18-month randomized controlled trial in the Niger Delta to evaluate whether a targeted antioxidant micronutrient regimen can reduce polycyclic aromatic hydrocarbon (PAH) biomarkers and improve neonatal outcomes among women of reproductive age exposed to oil-related environmental toxins.

Kellybest Davids2026-07-02
📄 medicine

Beyond the Tap and the Latrine: Sanitation, Clean Drinking Water, and the Fight Against Child Stunting a Systematic Mapping Review of Evidence, Mechanisms, and Interventions

This systematic mapping review synthesizes evidence from 2010 to 2023 to demonstrate that inadequate sanitation and unsafe drinking water drive child stunting primarily through environmental enteric dysfunction, highlighting the need for context-specific, multi-sectoral WASH and nutrition interventions to achieve significant reductions in growth failure.

cahyani wulandari, Moses Glorino Rumambo Pandin2026-07-02
📄 medicine

Turnover intention and associated factors among employees of regional and city health regulatory bodies in Ethiopia. A cross-sectional study

This cross-sectional study conducted in Ethiopia reveals that 55.5% of employees in regional and city health regulatory bodies intend to leave their jobs, a trend significantly driven by dissatisfaction with salaries and organizational environments, as well as family separation, while adequate educational infrastructure for children serves as a protective factor.

Fitsum Zekarias, Sirak Damtew, Getahun Gebre, Tadesse Mamo, Esubalew Tesfahun, Mekasha Getnet2026-07-02
📄 medicine

Multilayered validation of graph attention autoencoder–derived drug repurposing candidates for COVID-19

This study presents a multilayered validation framework combining a Graph Attention Autoencoder (GATE) with real-world data and phenome analyses to identify and prioritize novel COVID-19 drug repurposing candidates, specifically highlighting cilastatin and megestrol as promising therapeutics supported by statistical and mechanistic evidence.

Yusuke Nakayama, Shingo Tsuji, Koji Yamamoto, Juran Kato-Suzuki, Kouichi Hosomi2026-07-02