13396 papers
This case report describes a 10-year-old girl with anti-factor H antibody-associated atypical hemolytic uremic syndrome linked to a homozygous CFHR1-CFHR3 deletion, who achieved full clinical and renal recovery following early therapeutic plasma exchange and corticosteroid treatment.
This qualitative study of Thuthuzela Care Centres in South Africa reveals that while some survivors appreciate the dignity and communication during medico-legal rape examinations, the overall quality and forensic utility of the process are significantly compromised by systemic challenges such as staff shortages, resource delays, and procedural inconsistencies, necessitating a holistic approach that strengthens coordination and support across health and legal sectors.
This single-centre overlap-weighted cohort study suggests that using self-expanding metallic stents as a bridge to surgery for obstructing colorectal cancer increases the likelihood of favorable definitive outcomes (laparoscopic, stoma-free resection without major complications) compared to emergency resection, although the findings are imprecise and sensitive to statistical adjustments.
This cross-sectional study in Bahrain reveals that while most parents are open to HPV vaccination, low awareness and safety concerns persist, with positive attitudes and healthcare provider recommendations being the primary drivers of willingness to vaccinate rather than knowledge alone.
This systematic review of 31 studies on end-of-life shared decision-making in adult ICUs reveals that while the "Team Talk" phase is well-established, the "Option Talk" phase remains the least consistently operationalized component, highlighting a critical need to better integrate patient values and compare treatment options within the Three-Talk Model framework.
A case-control study conducted in the Kamina Health Zone, DRC, identified low educational attainment, smoking, contact with TB patients, and inadequate diet as significant risk factors for tuberculosis, highlighting the need for targeted prevention and nutritional interventions in this region.
This in silico simulation study demonstrates that constraining either the peak plasma concentration or the maximum infusion rate during Eleveld target-controlled propofol induction in elderly patients significantly reduces plasma overshoot with only a minimal delay in reaching the desired effect-site target, offering a potential strategy to improve haemodynamic safety.
This study of 11 million deaths across 14 Brazilian federative units from 2014 to 2024 reveals that the acute mortality risk from extreme heat increases significantly with age, being approximately three times higher for those aged 85 and older compared to those under 65, with no statistically significant evidence of compensatory mortality reduction (mortality displacement) within a 21-day window, thereby supporting the prioritization of adults aged 75 and older in heat response plans.
While the spatial distance between QRS and T loops shows a strong association with reduced ejection fraction in hospital ECGs, this study concludes that the relationship may be driven by differential measurement error rather than independent predictive value, necessitating external replication before clinical utility can be established.
This literature review of studies from 2014 to 2024 concludes that both allergen-specific immunotherapy and biologic agents are effective and safe options for managing respiratory allergies, with treatment selection depending on individual patient characteristics and disease severity.