13396 papers
While virtual reality boxing reduced depressive symptoms to a similar degree in autistic and non-autistic young adults, the intervention suffered significantly higher dropout rates among autistic participants, highlighting the need for improved onboarding strategies in future trials.
This study presents a platelet membrane-camouflaged Prussian blue/manganese dioxide nanobiomimetic that leverages its high photothermal conversion efficiency and biomimetic targeting to achieve effective, low-toxicity tumor ablation in both in vitro and in vivo models.
The study identifies VCB1, a novel ATP citrate lyase (ACLY) inhibitor, as a potent therapeutic agent that overcomes tyrosine kinase inhibitor resistance in lymphoma by disrupting lipid and nucleotide metabolism, activating the integrated stress response, and impairing redox homeostasis.
This comparative pharmacovigilance study of FAERS data indicates that while semaglutide and tirzepatide are associated with similar rates of mortality and hospitalization following pulmonary aspiration, tirzepatide cases are significantly more likely to be designated as life-threatening.
This study demonstrates that quinoid dihydropteridine reductase (QDPR) exhibits a stroma-enriched distribution in the colon and is significantly downregulated in ulcerative colitis lesions compared to healthy tissue and Crohn's disease, suggesting its potential utility as a biomarker for distinguishing inflammatory bowel disease subtypes and assessing mucosal repair.
This study conducted a pre-implementation needs assessment for the "Growing Up Healthy and Happy" family-based prevention programme in Munich using the CFIR 2.0 and ERIC frameworks to identify organizational facilitators and barriers, ultimately deriving tailored strategies to support its implementation and sustainability for children of parents with depression.
This retrospective cohort study of 527 HIV patients in Addis Ababa demonstrates that implementing the Universal Test and Treat strategy significantly improved patient survival and reduced mortality compared to the previous CD4-based treatment approach.
This integrated meta-analysis and bioinformatics study demonstrates that sacubitril/valsartan significantly improves cardiac function and prevents cardiotoxicity in breast cancer patients, identifying PIK3CG and KEAP1 as potential causal therapeutic targets.
This study identifies an interferon-responsive MP4-high cancer-associated fibroblast subtype in high-grade serous ovarian cancer that orchestrates immune cell recruitment to create an immune-active tumor microenvironment, thereby serving as a positive prognostic biomarker and suggesting exogenous interferon stimulation as a potential therapeutic strategy.
This study reveals that breast cancer stem cells resist TROP2-targeted CAR-T therapy through the activation of the NF-κB signaling pathway, suggesting that targeting this mechanism could improve treatment outcomes.