6238 papers
The paper introduces ECG-LLM, a large language model trained on over 679,000 ECG studies that leverages multimodal supervision to enable question-driven cardiovascular reasoning, allowing front-line clinicians to derive complex cardiac phenotypes and diagnostic insights directly from 12-lead ECGs without immediate access to advanced imaging.
This study demonstrates that an explainable machine learning model utilizing organ-specific dosiomics features from CyberKnife SBRT plans can effectively predict late genitourinary toxicity in prostate cancer patients, achieving high accuracy while identifying clinically interpretable risk drivers through SHAP analysis.
This study demonstrates that structure-guided small molecules can selectively target a unique RNA conformation induced by the CFTR W1282X mutation to stabilize the transcript, thereby partially restoring CFTR function in cystic fibrosis cells.
In a propensity-matched study of an Asian population, kinematic alignment in primary total knee arthroplasty demonstrated comparable or superior two-year functional outcomes and patient satisfaction relative to mechanical alignment, with equivalent safety and revision-free survival rates.
This prospective observational study found that while microplastics are universally present in the bronchoalveolar lavage fluid of both newly diagnosed lung cancer patients and controls, their densities are comparable between the two groups, suggesting that these particles reflect general environmental inhalation rather than serving as a specific indicator of malignancy.
This study combines a single-center cohort analysis and a meta-analysis to reveal that the risk of stroke-associated pneumonia following intracerebral hemorrhage is significantly higher than previously reported, with evidence suggesting a concerning upward trend in incidence since 2019.
In a large nationwide Korean cohort study, initiating SGLT2 inhibitors as second-line therapy for type 2 diabetes was associated with a significantly lower 180-day risk of acute kidney injury compared to sulfonylureas, a protective effect that persisted in patients with heart failure but was attenuated among those with pre-existing chronic kidney disease.
This retrospective cohort study of 2,242 cardiac surgery patients demonstrates that postoperative vasopressor-inotropic requirements and intraoperative hypotension serve as significant, partially modifiable mediators linking preoperative pulmonary hypertension to an increased risk of acute kidney injury.
This cross-sectional analysis of the Beichen Eye Study involving 4,748 participants aged over 50 found that a higher triglyceride-to-HDL cholesterol ratio and lower triglyceride levels were associated with a reduced prevalence of age-related macular degeneration, while HDL cholesterol alone showed no independent association.
This study utilizes 3D-CT to characterize the anatomical variations of the first jejunal trunk (FJT) relative to the superior mesenteric artery, revealing that the Ventral type exhibits more cranial venous confluence and a greater relative venous contribution than the Dorsal type, which has significant implications for preoperative planning in pancreaticoduodenectomy.