📄 Category

medicine

6238 papers

📄 medicine

Deep Learning-Based Whole-Body Lesion Segmentation and Automated OMIS Computation on [68Ga]Ga-DOTA-TOC PET/CT: Technical Feasibility of a SwinUNETR Pipeline for Pre-PRRT Bone Marrow Involvement Scoring

This study demonstrates the technical feasibility of a SwinUNETR-based deep learning pipeline for automated whole-body lesion segmentation and Osteo-Medullary Invasion Score (OMIS) computation on [68Ga]Ga-DOTA-TOC PET/CT, achieving performance comparable to expert inter-observer agreement and offering a reproducible tool for pre-PRRT risk stratification in neuroendocrine tumor patients.

Romain Ferrara, Solène Malmon, Salim Kanoun, Joris Cocquebert, Thibaut Reichert, Adil Moussali, Nathalie Charrier, Sébas (…)2026-07-03
📄 medicine

Successful Reversal of Tachycardia Induced Cardiomyopathy After Flecainide Therapy in an Infant With Focal Atrial Tachycardia

This case report describes the successful reversal of tachycardia-induced cardiomyopathy in a 4.5-month-old infant with focal atrial tachycardia through the prompt initiation of flecainide therapy, which restored sinus rhythm and led to the complete recovery of ventricular function and clinical status after initial rate-control strategies failed.

Arife Sancaktar, Tuğba Burcu Öztürk Gömeç, İrem Ersayoğlu2026-07-03
📄 medicine

Development and Internal Validation of a Simple Four-Variable Model for Predicting High-Risk Varices in Patients with Virally Suppressed HBV-Related Cirrhosis

This study developed and internally validated a simple four-variable model incorporating albumin, alanine aminotransferase, prothrombin time activity, and splenomegaly that demonstrates superior predictive accuracy for high-risk varices in patients with virally suppressed HBV-related cirrhosis compared to established non-invasive scores.

Xu Huang, Shaofei Wu, Wenhua Liu, Hao Zhuo, Ziheng Zhang, Yong An, Liwei Guo2026-07-03
📄 medicine

Transpulmonary pressures to predict the percentage of alveolar collapse and overdistension in acute respiratory distress syndrome

This study demonstrates that end-expiratory and end-inspiratory transpulmonary pressures accurately predict critical thresholds of alveolar collapse and overdistension in ARDS patients, yet EIT-guided PEEP titration yields higher pressures and improved recruitment compared to esophageal pressure-guided strategies, albeit with a trade-off of increased non-dependent overdistension.

Clément Brault, Yoann Zerbib, Romain Vallee, Rosalie Schoux, Alexis Lambour, Benjamin Swinyard, Valentin Dambrine, Julie (…)2026-07-03
📄 medicine

Adonertinib (FHND9041) versus Afatinib as First-line Treatment for Advanced Non-small-cell Lung Cancer with EGFR Sensitive Mutation (FHND9041-Ⅲ-01): A Multi-centre, Open-label, Randomised Phase 3 Trial

In a multi-centre, open-label, randomised phase 3 trial, adonertinib demonstrated significantly superior progression-free survival and a more favorable safety profile compared to afatinib as a first-line treatment for patients with advanced EGFR-mutated non-small-cell lung cancer, particularly those with Ex19del mutations.

Yuankai Shi, Puyuan Xing, Guowu Wu, Hongbo Wu, Xuhong Mi, Renping Wan, Chao Zhang, Yan Wang, Runxiang Yang, Hui Zhao, Ch (…)2026-07-03
📄 medicine

The projected dementia burden attributable to periodontal disease in England: a modelling study

This modelling study projects that the anticipated growth in periodontal disease prevalence in England could result in over 24,000 additional dementia cases and £548 million in annual societal costs by 2040, highlighting it as a highly prevalent but weak modifiable risk factor where population-level interventions may yield significant benefits despite minimal individual risk.

Edward Coote, Nitesh Patel, Rajesh Vijayanarayanan2026-07-03
📄 medicine

Short-Term Outcome and Associations of Mortality in Children Admitted with Severe Malaria in a Tertiary Health Facility, in South East, Nigeria

This retrospective study of 434 children admitted with severe malaria at a tertiary hospital in South-East Nigeria reveals a 12.2% mortality rate, identifying age under five, urban residence, delayed presentation, and severe clinical complications like shock and impaired consciousness as significant independent predictors of death.

Joseph Ezeogu, Chidi Jude Okoro2026-07-03
📄 medicine

Association Between Insulin Resistance and Obstructive Sleep Apnea in Non-Diabetic Obese Children

This study demonstrates that in non-diabetic obese children, insulin resistance (measured by HOMA-IR) is independently associated with the severity of obstructive sleep apnea, suggesting it could serve as a useful adjunct marker for identifying high-risk patients.

Birce Sunman, Didem Alboğa, Meltem Akgül Erdal, Havva İpek Demir, Burcu Şenkalfa, Doğuş Vurallı, Nagehan Emiralioğlu Ord (…)2026-07-03
📄 medicine

Obesity and fibromyalgia predict the development of “difficult-to-manage” psoriatic arthritis phenotype associated with adverse outcome

This prospective cohort study reveals that obesity and fibromyalgia are independent predictors of a "difficult-to-manage" psoriatic arthritis phenotype, which is associated with higher functional impairment, serious adverse events, and hospitalizations compared to non-difficult-to-manage cases.

Antonios Bertsias, Irini Flouri, Evgenia Emmanouilidou, Argyro Repa, Eleni Kalogiannaki, Sofia Pitsigavdaki, Nestor Avgo (…)2026-07-03
📄 medicine

Bony trigeminal nerve entrapment in autosomal dominant osteopetrosis: a rare cause of secondary trigeminal neuralgia

This paper reports a successful case of complete resolution of refractory trigeminal neuralgia in a patient with autosomal dominant osteopetrosis type 1, achieved through a pretemporal extradural transcavernous approach that decompressed the nerve by addressing bony entrapment caused by petrous bone osteosclerosis.

Sarah Hendrickx, Ruben Dammers, Victor Volovici2026-07-03