📄 medicine

Characterization of acute dengue immune status and the role of serotypes in transmission dynamics in three regions of Burkina Faso: a hospital-based cross-sectional study

This hospital-based cross-sectional study in Burkina Faso characterizes acute dengue immune status and transmission dynamics, revealing a predominance of primary infections and DENV-1/3 circulation, validating a rapid diagnostic test for immune status differentiation, and suggesting the Qdenga vaccine as a relevant intervention option.

Louis Robert Wendyam Belem, Arsène Zongo, Raymond Karlhis Yao, Christelle Lankouandé, Armand Vital Wenceslas Taïta, Tarw (…)2026-07-02
📄 medicine

Early Regression of Hepatic Steatosis after Bariatric Surgery Assessed by Ultrasound Including Attenuation Imaging

This prospective study demonstrates that hepatic steatosis regresses significantly within the first three to six months following bariatric surgery, with quantitative Attenuation Imaging (ATI) proving more sensitive than standard B-mode ultrasound for detecting these early improvements and enabling precise longitudinal monitoring.

Tatjana Hoffmann, Daniel Wulff, Sabrina Groß, Bariya Bajwa, Gunnar Blumenstock, André Mihaljevic, Nisar Malek, Lisa Minn2026-07-02
📄 medicine

Risk of Desmoid Tumor Based on APC Pathogenic Variant Location and Surgical History in Familial Adenomatous Polyposis: A U.S. Community Cohort Study

In a large U.S. community-based cohort of patients with familial adenomatous polyposis, the study identifies that central *APC* variant location, family history, and prior colorectal surgery are significant independent risk factors for developing desmoid tumors, whereas non-colorectal surgery is not.

Prakash Thomas, Holly Carwana, Sheng-Fang Jiang, Janet Song, Dan Li2026-07-02
📄 medicine

A Practical Scoring System for Conversion Therapy Stratification in Intermediate-Stage Hepatocellular Carcinoma

This study presents and externally validates the CATCH score, a practical three-factor tool (incorporating albumin–bilirubin score, BMI, and des-γ-carboxyprothrombin) that effectively stratifies patients with intermediate-stage hepatocellular carcinoma to identify candidates most likely to achieve successful conversion therapy with atezolizumab plus bevacizumab.

Kenichi Taguchi, Yasuto Takeuchi, Masahiko Sue, Takuya Adachi, Hideki Onishi, Miwa Kawanaka, Akinobu Takagi, Kenji Kuwak (…)2026-07-02
📄 medicine

Proximity without sovereignty: community-led responses and the UNAIDS 30-80-60 targets in HIV governance in Kinshasa, DRC: a qualitative study

This qualitative study in Kinshasa reveals that despite the vital role of community actors in HIV service delivery, their influence remains limited to consultation rather than strategic decision-making—a condition termed "proximity without sovereignty"—which necessitates structural reforms like core funding and legal protections to achieve genuine community-led governance.

KANA LINGAMBU Olivier, Silvia ROSSI, MAINDO ALONGO Mike-Antoine, KAMBAMBA MANDEKI Dina, Philippe LUKANU2026-07-02
📄 medicine

Plasma proteomic profiling reveals distinct molecular signatures associated with coronary collateral circulation in patients with chronic total occlusion

This study utilizes plasma proteomic profiling to identify distinct molecular signatures and develop a high-accuracy machine learning model that effectively predicts coronary collateral circulation status and stratifies cardiovascular risk in patients with chronic total occlusion.

Yi-Ning yang, Jun-Yi Luo, Peng Ran, Fen Liu, Ya-Jing Qiu, Bin-Bin Fang, Yunzhi Wang, Sha Tian, Xiao-Mei Li, Chen Ding2026-07-02
📄 medicine

Physiological comparison of high-flow oxygen via endotracheal tube and T-piece strategies during spontaneous breathing trials: a randomized crossover study

This randomized crossover study demonstrates that high-flow oxygen delivered via an endotracheal tube, particularly with smaller expiratory ports and higher flow rates, generates beneficial pressure-dependent physiological effects—including improved lung volume, oxygenation, and reduced dynamic stress—while maintaining inspiratory effort comparable to post-extubation levels, positioning it as a promising alternative to T-piece strategies for spontaneous breathing trials.

Shan-Shan Xu, Rui-Zhi Zhang, Jun-Tong Liu, Lin Wang, Meng-Xue Hou, Xu An, Ming-Yue Miao, Hong-Liang Li, Yue-Fu Wang, Jia (…)2026-07-02
📄 medicine

Rapid evaluation of risk communication and population acceptance following detections of vaccine-derived poliovirus in wastewater, Germany, 2024–2025

Despite high overall vaccine acceptance in Germany following 2024–2025 wastewater poliovirus detections, limited risk communication achieved only moderate reach and failed to close vaccination gaps, particularly among parents with populist political orientations who exhibited lower trust and uptake.

Julia Neufeind, Cornelius Rau, Johannes Lemcke, Ole Wichmann, Nora Schmid-Küpke2026-07-02