📄 medicine

The Impact of Artificial Intelligence on the Accuracy of Interproximal Reduction Simulation in Clear Aligner Therapy: A Scoping Review

This scoping review synthesizes evidence from 19 studies (2022–2026) to demonstrate that AI measurably influences interproximal reduction simulation accuracy across clear aligner therapy workflows, while highlighting the critical need for dedicated prospective studies comparing AI-simulated versus conventional IPR outcomes.

Fadi Mohammed Altawil, Mohammed Abdulaziz Korayem, Hisham Ibrahim AlHazmi, Maan Mustafa Mahmoud2026-07-16
📄 medicine

An algorithmic process to develop clinical practice guideline recommendations based on meta-analyses of the relevant evidence

This paper presents an algorithmic process and accompanying resources to help clinical practice guideline development teams synthesize meta-analysis evidence into recommendations, thereby reducing subjective bias and enhancing reproducibility in physical therapy.

Pierce Boyne, Emily Fox, Dorian Rose, Michael Lewek, Christina Garrity, Daria Pressler, Julie Braun, Steven Walczak, Jol (…)2026-07-16
📄 medicine

The Illusion of "Less Sugar": How Regulatory Loop-Hole in Carbonated Soft Drink Labeling Sustains Non-Communicable Disease (NCD) Risks in Nigeria

This study argues that Nigeria's reliance on the Codex Alimentarius's 25% relative sugar reduction standard for "Less Sugar" carbonated soft drinks fails to protect public health by allowing products to retain hazardous absolute sugar levels, necessitating a regulatory shift to a stricter 60% reduction threshold and mandatory warning labels to effectively mitigate Non-Communicable Disease risks.

CHRISTOPHER ENASOR FREGENE, Dike Bevis Ojji, Abimbola Opeyemi Adegboye2026-07-16
📄 medicine

Modeling the Public Health Impact of Sodium Reduction in Nigerian Bread: An Intake Assessment and Risk Reduction Simulation Analysis

This study demonstrates that commercially baked bread in Nigeria contains critically high sodium levels exceeding global standards, and simulates that implementing mandatory reformulation targets of 250–370 mg/100g could reduce population sodium exposure by 41.7% to 60.0%, offering a scalable strategy to lower cardiovascular disease burdens despite the need to navigate industrial and trade challenges.

CHRISTOPHER ENASOR FREGENE, Dike Bevis Ojji, Abimbola Opeyemi Adegboye2026-07-16
📄 medicine

In Silico Drug-Likeness Assessment of Phytochemicals from Alpinia zerumbet Using Molecular Property Prediction

This study utilized in silico molecular property prediction to evaluate twenty phytochemicals from *Alpinia zerumbet*, revealing that most, particularly 1,8-cineole and linalool, satisfy Lipinski's Rule of Five and exhibit favorable drug-likeness characteristics for potential oral drug development.

Shailendra S. Suryawanshi, Sahil Sanjay Kadolkar, Arif Salim Jamadar, Ronak Dsouza, Adarsh Anil Kamate2026-07-16
📄 medicine

Negative pressure isolation chamber for aerosol generating procedures: a randomized feasibility simulation trial

This randomized feasibility simulation trial found that while the Negative Pressure Isolation Chamber (NPIC) significantly reduced aerosol exposure during intubation, it also prolonged intubation time and emergency diagnosis, raising concerns about its clinical usability.

Alberto Baldelli, Andrew Poznikoff, Nicholas West, Jeffrey N. Bone, Matthias Görges, Robert Purdy2026-07-16
📄 medicine

Establishing The Australian Undiagnosed Disease Network (UDN-Aus); Australia’s first national rare disease diagnostic network

This paper outlines the establishment, methodology, and key findings of the Australian Undiagnosed Disease Network (UDN-Aus), Australia's first national initiative designed to improve genomic diagnosis rates for undiagnosed rare diseases through a collaborative multi-site research program.

Ellenore M Martin, Madeleine Harris, Tegan Stait, Sarah Casauria, Esther Pierini, Susan M White, Azure Hermes, Julie McG (…)2026-07-16
📄 medicine

Can Multimodal Large Language Models Replace Expert Assessment in Preclinical Endodontic Education? A Cross-Sectional Agreement Study

This study demonstrates that current multimodal large language models systematically overestimate the quality of preclinical endodontic preparations and lack the reliability of expert endodontists, particularly regarding safety-critical judgments, indicating they are unsuitable as replacements for human assessment in dental education.

Assist. Prof. Dr. SANA MAHROOS AL-SHAMMARI, Assist. Prof. Dr. MELİSA USLU, Assoc. Prof. Dr. IŞIL KAYA BÜYÜKBAYRAM, Resea (…)2026-07-16
📄 medicine

Achievement of Pathological Complete Response with Neoadjuvant Ensartinib in a Patient with Locally Advanced ALK-Rearranged Lung Squamous Cell Carcinoma: A Case Report and Literature Review

This case report demonstrates that neoadjuvant treatment with ensartinib combined with chemotherapy achieved a pathological complete response in a patient with locally advanced ALK-rearranged lung squamous cell carcinoma, a rare subtype lacking established neoadjuvant guidelines.

Kang Guo, Wu Ping Wang, San Ming Deng, Jun Feng Bai2026-07-16