medicine papers | Gist.Science

Association between insulin resistance surrogate indices and incident chronic kidney disease among the population with cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study

In a cohort of Chinese adults with cardiovascular-kidney-metabolic syndrome stages 0–3, composite insulin resistance indices incorporating anthropometric measures (such as TyG-BMI and TyG-WHtR) demonstrated a more robust and independent association with incident chronic kidney disease than the triglyceride-glucose index alone, despite all indices showing limited predictive discrimination.

Jianrong Wu, Mengyue Lin, Xuerui Tan, Yequn Chen2026-10-20

📄 medicine

Access-related Barriers to Early Antenatal Booking by Pregnant Mothers in South Africa: An Exploratory Design

This qualitative study explores the access-related barriers preventing pregnant women in South Africa from booking early antenatal care, identifying key challenges in literacy and knowledge, socio-economic constraints, and health system deficiencies that collectively delay essential maternal healthcare.

Sharon Hlanganani Maluleke-Ngomane2026-10-20

📄 medicine

Can Video Laryngoscopy Enhance Direct Laryngoscopy Skills in Novice Medical Students? A Randomized Crossover Trial (ViDiLa)

This randomized crossover trial involving novice medical students found that while supervised video laryngoscopy training improved subsequent direct laryngoscopy performance compared to starting with direct laryngoscopy, it did not substitute for device-specific practice and initially proved more challenging than direct laryngoscopy itself.

Jannis Schwanemann, Jonathan Nübel, Patrick Vetterling, Larissa Land, Nora Schiller, Stella-Karolin Krispin, Mareike Kri (…)2026-10-20

📄 medicine

Rutaecarpine mediates phenotypic transition of vascular smooth muscle cells via ADAM17-TNF-NLRP3 signaling pathway

This study demonstrates that rutaecarpine inhibits angiotensin II-induced vascular smooth muscle cell phenotypic transition by suppressing the ADAM17-TNF-NLRP3 signaling pathway.

Hai-Hong Tian, Ying Liu, Pei-Qi Shi, Yan Yang, Yan-Fang Chen, Chun Zhou, Si-Yu Zeng2026-10-20

📄 medicine

Laparoscopic Versus Robot-Assisted Radical Prostatectomy: Outcomes for pT3-4N0-1M0 Prostate Cancer

This study demonstrates that while both laparoscopic and robot-assisted radical prostatectomy are effective and safe for treating locally advanced pT3–4N0–1M0 prostate cancer, the robot-assisted approach offers a shorter operative time and superior early continence recovery.

Yi Yang, Xiaohong Han, Jianli Cheng, Xinhui Liao, Jieqing Chen, Zhongfu Zhang, Jianting Wu, Chenglong Wu, Yuhan Liu, Yiw (…)2026-10-20

📄 medicine

Schema-aware maintenance improves temporal calibration of prostate cancer survival predictions

This study demonstrates that a schema-aware, utility-gated maintenance strategy significantly improves the temporal calibration of a frozen prostate cancer survival model using SEER data, reducing prediction errors by 6.55% while preserving discriminative performance.

Said Elshafae, Sayed Youssef, Rania Elshafae, Maha Moussa2026-10-20

📄 medicine

Albumin Quantification in Body Fluids Using Material Decomposition on Dual-Energy CT: An In Vitro Feasibility and Threshold Analysis

This in vitro study demonstrates that dual-energy CT material decomposition is a feasible method for quantifying albumin in various body fluids with high correlation to ELISA, particularly at concentrations of 17 mg/mL or higher, though fluid-specific calibration and further validation are required before clinical application.

Dong Liu, Shiji Wu, Suping Chen, Congcong Liu, Jing Zhang, Qiuxia Wang2026-10-20

📄 medicine

High-Dose Ifosfamide in Relapsed Advanced Synovial Sarcoma: A Phase II Study of Efficacy and Health-Related Quality of Life outcomes from India

This Phase II study from India demonstrates that high-dose ifosfamide (11 g/m²) offers substantial efficacy and durable disease control for patients with relapsed advanced synovial sarcoma, providing a vital therapeutic option in resource-limited settings despite significant toxicity and quality of life trade-offs.

Vinith Kumar P R, Sameer Rastogi, Akash Singh, Kinjal Singh, Chitrakshi Nagpal, Lekha Kumar, Shamim Ahmed Shamin, Adarsh (…)2026-10-20

📄 medicine

Access to and Utilisation of Primary Healthcare Services among North-South Migrants in Kumasi, Ghana: A Cross-Sectional Mixed-Methods Study

This mixed-methods study of north-south migrants in Kumasi, Ghana, reveals that while physical access to healthcare facilities is high, utilization remains low due to financial constraints, inadequate National Health Insurance Scheme coverage, long waiting times, and cultural barriers, with usage patterns significantly influenced by gender, marital status, employment stability, and duration of stay.

Seth Oppong-Mensah, Daniel Buor, Prince Osei Wusu Adjei, David Forkuor2026-10-20

📄 medicine

Preparation and in‑vitro screening of yak‑skin collagen/PMVE‑MA composite biomaterials toward biodegradable vascular stents

This study develops a biodegradable yak-skin collagen/PMVE-MA composite for vascular stents that offers improved thermal stability and hemocompatibility but requires surface modification to overcome its inherent hydrophobicity, which currently hinders essential cellular adhesion and infiltration.

Songhao Liu, Juan Yan, Yuxia Zhang, Lin Rong, Liang Gao, Lixin Wei, Hongxia Yang, Mengyu Gao2026-10-20

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