6270 papers
This single-center study in China demonstrates that combining trio whole-exome sequencing with copy number variation sequencing significantly improves the diagnostic yield for developmental delay and intellectual disability in children, while also identifying novel genetic variants and suggesting potential roles for nitrogen and sulfur metabolism in the condition's pathogenesis.
In a Chinese pediatric cohort, elevated pan-immune-inflammation value (PIV) was observed across all tic disorder subtypes compared to healthy controls, with a unique sex-specific inverse association between higher PIV and lower tic severity found only in males with transient tic disorder.
This study demonstrates that phosphatidylserine (PS) treatment, particularly at a dose of 40 mg/kg, significantly promotes functional recovery and reduces neuropathic pain in a rat spinal cord injury model by suppressing inflammatory cytokines and inhibiting key signaling pathways (MAPK, ERK1/2, and NF-κB), thereby offering a promising therapeutic adjunct to current treatments.
This study demonstrates that the home literacy environment is a central and independent predictor of early literacy development in children with cochlear implants, significantly outweighing the influence of demographic and implant-related variables.
This study estimates that in Pennsylvania, a lung cancer prevention strategy targeting current smokers in high-radon homes is the most cost-effective approach, potentially preventing approximately 1,000 deaths over 35 years at roughly 11% of the cost of a population-wide mitigation strategy.
This systematic review proposes that the architectural pattern of inflammatory glomerular injury is determined not merely by the presence of complement deposition, but specifically by its endothelial accessibility, which dictates whether neutrophil-mediated damage occurs within the glomerular capillary lumen or in extraglomerular compartments.
This multicenter Italian retrospective study demonstrates that IRRAflow®-based active cerebrospinal fluid exchange is a feasible and generally safe real-world intervention for managing difficult CSF in neurocritical care, showing significant clinical improvement despite higher adverse event rates in infectious compared to hemorrhagic cases.
The University of Central Florida's "Clinician Educator" model addresses primary care shortages and traditional clerkship limitations by restructuring outpatient training to prioritize student autonomy, standardized teaching, and skill development through a modified clinic workflow that balances educational goals with clinical productivity.
This systematic review and meta-analysis of 45 prospective studies involving over 48,000 adults found that while greater baseline flexibility is weakly associated with reduced risks of future pain, disability, and frailty, current evidence provides limited support for flexibility as an independent predictor of broader health outcomes due to methodological limitations and low certainty of evidence.
This systematic review and meta-analysis of 35 prospective cohort studies concludes that while general flexibility shows limited value as a prognostic marker for chronic conditions, specific joint range-of-motion assessments may offer clinical utility for certain diseases like osteoarthritis and ankylosing spondylitis, though high-quality longitudinal evidence remains scarce for most major chronic conditions.