📄 Category

medicine

6270 papers

📄 medicine

Analysis of spatial-temporal distribution and influencing factors of pulmonary tuberculosis in Mainland China based on geographic information system, 2014-2023

This study analyzes 2014–2023 data to reveal that while pulmonary tuberculosis incidence and mortality in Mainland China have generally declined, the disease exhibits significant spatial clustering in the northwest and humid, economically developed regions, with incidence negatively associated with health expenditure and medical staffing but positively linked to illiteracy rates.

Xinzhu Xiao, Yuping Zhan, Yunfei Chen, Qichao Fan, Junjin Liu, Jiaofeng Huang, Haibo Ding2026-07-02
📄 medicine

Trends in mortality among decedents with coexisting neoplasms and cardiac arrhythmias in the United States, 1999–2024

This study reveals that from 1999 to 2024, age-adjusted mortality rates among US adults aged 65 and older with coexisting neoplasms and cardiac arrhythmias increased substantially, with the highest burdens observed in males, non-Hispanic White individuals, the oldest age groups, and residents of the South and non-metropolitan areas, highlighting urgent needs for targeted cardio-oncology strategies and equitable care.

Pari Kotak, Armeen Shahzad, Syed Shayan Ali, Maryam Waqar, Muhammad Vazaym, Muhammad Jawad, Amisha Kumari, Faiz Un Nisa2026-07-02
📄 medicine

Functional Compensation of Substantia Nigra by Locus Coeruleus in Parkinson’s Disease

This study utilizes multimodal MRI to demonstrate that in Parkinson's disease, the locus coeruleus exerts a substantial functional compensatory influence on the substantia nigra, a mechanism supported by complementary network-level effects and distinct patterns of neuromelanin loss compared to mild cognitive impairment.

Qiang Liu, ZeZhong Zheng, LuHao Cui, Pan Wang, Feng Xue, QiChao Cheng, YiLei Xiao, WenChao Duan, Teng Chen, FanGang Meng (…)2026-07-02
📄 medicine

In vitro and in vivo Immunotherapy effect of Rosmarinus officinalis and Hygrophila spinosa cultivated from Nilgiri hills origin, India: A Comparative Study of Pharmacognostical, Toxicological, Phytochemical and Preclinical Analysis

This study demonstrates that water-ethanolic extracts of *Rosmarinus officinalis* and *Hygrophila spinosa* from the Nilgiri Hills are safe, potent antioxidants and immunomodulators, with *R. officinalis* showing superior immunostimulatory potential in reversing cyclophosphamide-induced immunosuppression in mice.

Dolly Rani, Puja Saha, Paramita Ganguly, Sandip Chatterjee, Pawan Kumar Goswami2026-07-02
📄 medicine

The Impact of COVID-19 Within Stage Migration and Upstage in Multiple Cancer Lineages

This retrospective study of over 16,000 patients reveals that the COVID-19 pandemic had a heterogeneous impact on cancer staging trends across different lineages, causing significant upstaging in lung, prostate, and colorectal cancers while paradoxically showing downstaging in breast cancer, with no significant changes observed for pancreatic and gastric cancers.

Lacey Mead, Eden Crowsey, Donald Davis, Manuel Molina, Toan Nguyen2026-07-02
📄 medicine

Sublingual bivalent vaccination with PspA-C-CPE and Alcaligenes lipid A induces protective immunity against both Streptococcus pneumoniae and Clostridium perfringens

This study demonstrates that a novel sublingual bivalent vaccine combining the fusion protein PspA-C-CPE with Alcaligenes lipid A elicits robust, long-lasting, and non-invasive protective immunity against both Streptococcus pneumoniae respiratory infections and Clostridium perfringens enterotoxin-mediated foodborne illnesses in mice.

Yuki Hirayama, Ken Yoshii, Atsushi Shimoyama, Keigo Iemitsu, Eri Node, Hiroshi Kiyono, Masuo Kondoh, Koichi Fukase, Jun (…)2026-07-01
📄 medicine

Role of Ultrasound Elastography in the Evaluation of Thyroid Nodules With Cytological Correlation

This prospective study demonstrates that ultrasound elastography, particularly when combining quantitative strain ratio analysis with qualitative assessment, significantly enhances the diagnostic accuracy and specificity for differentiating benign from malignant thyroid nodules compared to conventional TIRADS-based ultrasonography alone.

Sachin Khanduri, K Prithvi Perumal, Sajida Ansari, Kunal Nilambar Dwari, Sana Fatima, Prity Kumari, Yash milind Deole2026-07-01
📄 medicine

Admission and In-Hospital Laboratory Parameters Predict Mortality in Acute Paraquat Poisoning

This study of 119 Iranian patients demonstrates that admission and in-hospital laboratory parameters, specifically elevated creatinine, decreased oxygen saturation, and low potassium levels, serve as valuable prognostic indicators for mortality in acute paraquat poisoning, offering a practical alternative where specific urinary testing is unavailable.

Peyman Astaraki, Kiandokht Khorshidi, Mohammad Meshkini, Maryam Ahadi, Hamze Asadollahi2026-07-01
📄 medicine

Identifying the heterogeneity of physical resilience in Chinese older adult stroke patients using latent profile analysis and network analysis

This cross-sectional study of 346 Chinese older stroke patients utilized latent profile analysis and network analysis to identify three distinct physical resilience subgroups—low externally dependent, moderate balanced, and high proactive optimistic—revealing that education, comorbidities, and psychosocial factors predict profile membership while highlighting coping and lifestyle adjustment as core bridge nodes for targeted nursing interventions.

Maohua Li, Qing Li, Rong Tang, Yuqin Liu, Wei Xue, Yongkui Han2026-07-01
📄 medicine

A Highly Potent Nanomedicine for Precision Pancreatic Enzyme Replacement Therapy

This study presents PER301, a scalable, non-absorbable nanomedicine that integrates enzyme shielding, mucoadhesive retention, and biomimetic activation to achieve a 69-fold increase in digestive potency and fully restore lipid absorption in pancreatic insufficiency models, offering a stable and precise alternative to conventional oral enzyme therapies.

Manon Briand, Kristen Skvorak, Gabriele Specioso, Thomas Meister, John Watson, Christos Karamitros, Linda Martin, Megan (…)2026-07-01