medicine papers | Gist.Science

Efficacy and Safety of Unilateral Biportal Endoscopy Compared with Percutaneous Endoscopic Interlaminar Discectomy for the Treatment of Lumbar Lateral Recess Stenosis: A Minimum 6-month Follow-up

This retrospective study of 156 patients with lumbar lateral recess stenosis demonstrates that while unilateral biportal endoscopy (UBE) and percutaneous endoscopic interlaminar discectomy (PEID) share similar perioperative profiles, UBE provides superior long-term leg pain relief, functional recovery, and patient satisfaction at 6-month follow-up with no recurrence cases compared to PEID.

Bo Hu, Moqiang Li, Ke Xiao, Xiangbing Zeng2026-07-01

📄 medicine

An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung Cancer

This study identifies a specific SPP1+ macrophage and GZMK+ CD8+ T-cell axis in non-small cell lung cancer that drives immune checkpoint inhibitor resistance through spatial exclusion and signaling-mediated T-cell exhaustion, proposing a novel prognostic signature and therapeutic strategy to target this myeloid-lymphoid interaction.

zhejiong wang, Xiang Zhang, Chunbo Ma, Lichen Zhu, Yifei Wu, Ying Yu2026-07-01

📄 medicine

Advanced Hepatocellular Carcinoma in India Is Strongly Associated with Poor Surveillance: A Multicentre Study of 1,599 Patients.

This multicentre study of 1,599 Indian patients reveals that poor recognition of cirrhosis and low adherence to surveillance are the primary drivers of advanced hepatocellular carcinoma presentation, whereas prior surveillance significantly increases the likelihood of early-stage detection eligible for curative therapy.

Abraham Koshy2026-07-01

📄 medicine

Trends in psychological distress and associated disability in the Australian working population (2001–2022)

Over the last two decades in Australia, high psychological distress and disability support pension rates for psychiatric conditions have diverged, with distress rising significantly among young women since 2011 while overall pension payments declined due to policy changes, though they recently increased for younger age groups.

Mark Deady, Richard W. Morris, Aliza Werner Seidler, Daniel AJ Collins, Peter Butterworth, Samuel B Harvey2026-07-01

📄 medicine

Effects of local tranexamic acid on bleeding during rhytidectomy and post operative complication: randomized, controlled, single-blind trial

This protocol outlines a single-blind, randomized controlled trial at King Abdulaziz University Hospital designed to evaluate whether adding local tranexamic acid to tumescent solution during rhytidectomy reduces bleeding-related complications compared to tumescent solution alone.

Abdulaziz Saud Alenazi, Ahmed M Alarfaj, Amani A Obeid, Abdulaziz Alrabiah, Osama Alkaoud, Abdulaziz Alderaywsh, Leena R (…)2026-07-01

📄 medicine

Construction and Verification of A Prediction Model for Stranded Risk Nomograms in Emergency Department Patients

This study developed and validated a nomogram model using data from 25,391 emergency department patients to effectively predict the risk of prolonged stranded duration, thereby offering a practical tool for managing ED overcrowding.

Manman SHANG, Qin WEI2026-07-01

📄 medicine

Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Protective Effects of Fenofibrate in Acute Type A Aortic Dissection

This study utilizes single-cell RNA sequencing to characterize cellular heterogeneity in a mouse model of Acute Type A Aortic Dissection, identifying specific macrophage subpopulations and signaling pathways involved in the disease while demonstrating that fenofibrate exerts protective effects by modulating macrophage distribution and reducing inflammation.

Yang Yu, Dianna M Milewicz, Tianxiang Gu, Yulong Tian2026-07-01

📄 medicine

Dietary Intake Analyses for the Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis (PandrTB) Pharmacokinetic Sub-Study of the endTB and endTB-Q Clinical Trials

This study analyzed dietary intake data from 144 participants in the PandrTB pharmacokinetic sub-study to evaluate how food consumption, particularly fat content and nutrient levels in morning meals, may influence the absorption of key anti-tuberculosis drugs used to treat drug-resistant tuberculosis.

Loren Hans, Rina Swart, Gustavo E. Velásquez, Carole D. Mitnick, Lorenzo Guglielmetti, Fanny Garcia Velarde, Mahnoor Sah (…)2026-07-01

📄 medicine

Acute Peritoneal Dialysis Adequacy among Children at a National Referral Hospital in Kenya: A Cross-Sectional Study in a Resource-Limited Setting

This cross-sectional study at a Kenyan national referral hospital demonstrates that acute peritoneal dialysis effectively achieves measurable urea and creatinine clearance in children with acute kidney injury, resulting in a statistically significant reduction in serum solute levels after the first 24 hours of treatment.

Doreen Nganga, Bashir Admani, Dalton Wamalwa, Cyriaque Mbarubukeye2026-07-01

📄 medicine

Can Large Language Models Provide High-Quality Information for Patients with Multidrug-Resistant Organism Infections: A Multidimensional Comparative Analysis of DeepSeek-V3, ChatGPT-5.2, Gemini-3, and Grok-4

This study evaluates four large language models on their ability to generate patient education content for multidrug-resistant organism infections, finding that while Grok-4 achieved the highest scores in accuracy and safety, no model met acceptable standalone standards, necessitating mandatory expert review and human oversight before clinical use.

Yongxin Ma, Lei Li, Yige Shi, Zebing Ma, Mengyao Liu, Yingying Wang, Huayu Fan, Xiangyang Cao, Rui Chen2026-07-01

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