13414 papers
This study of Florida census tracts reveals that while perceived social isolation exhibits significant spatial clustering, accounting for this spatial dependence renders differences between urban, suburban, and rural areas statistically nonsignificant, suggesting that public health strategies should prioritize localized hotspots over broad administrative classifications.
This study demonstrates that a phage display-based workflow successfully identified and validated highly specific TCRs targeting the KRASG12V neoantigen and CTAG1B cancer-testis antigen, which, when engineered into T cells, effectively suppressed colorectal and esophageal tumors in xenograft models with minimal off-target toxicity.
This qualitative multistakeholder case study reveals that professional identity significantly shapes how Irish stakeholders define and prioritize training capacity for postgraduate medical expansion, leading to the development of an Educational Readiness Framework that reconciles conflicting service, educational, and regulatory demands to ensure sustainable growth.
This systematic review of 19 studies published between 2015 and 2025 reveals that women's chronic pain is shaped by a complex interplay of biological, psychosocial, and sociocultural factors—including gender roles and structural inequalities—necessitating a shift from purely biomedical models to integrative, gender-sensitive approaches in research and clinical practice.
This narrative review synthesizes research on immersive, embodied, and socially-oriented technologies for Alcohol Use Disorder, arguing for a conceptual shift from passive cue exposure to situated action where users actively rehearse coping strategies in ecologically valid environments, while positioning these tools as promising adjuncts to established treatments rather than standalone interventions.
This FAERS study indicates that momelotinib is disproportionately associated with reports of renal dysfunction and peripheral neuropathy in myelofibrosis patients compared to other JAK inhibitors, supporting the need for focused clinical monitoring despite the inability to establish causality.
This cross-sectional study of 679 clinical nurses reveals that higher self-efficacy and prior pulmonary rehabilitation training are significantly associated with improved knowledge, attitudes, and practices regarding pulmonary rehabilitation, suggesting that targeted interventions to boost self-efficacy could enhance care for COPD patients.
This qualitative study utilizing Colaizzi's method to analyze interviews with seventeen COPD patients identified five core unmet needs regarding follow-up services during the discharge transition period, including preferences for delivery formats, disease knowledge, professional consultation, psychological support, and seamless record management, to inform the development of improved transitional care systems.
This retrospective case-control study from Egypt found that prenatal maternal depression, anxiety, physical abuse, and low social support are independently and strongly associated with an increased risk of offspring neurodevelopmental disorders, supporting the need for routine mental health and violence screening in antenatal care within similar under-resourced settings.
This mixed-methods systematic review identifies that promoting physical activity among Muslim women requires context-sensitive, multi-level strategies that address barriers like modesty concerns and lack of safe spaces while leveraging facilitators such as religious motivation and culturally tailored programming, with distinct challenges and solutions emerging between majority and minority settings.