medicine papers | Gist.Science

Comparison of HAIC plus Targeted Immunotherapy and TACE plus Targeted Immunotherapy in Unresectable BCLC Stage C Hepatocellular Carcinoma with Up-to-11 High Tumor Burden: A Multicenter Retrospective Study

In a multicenter retrospective study of unresectable BCLC stage C hepatocellular carcinoma patients with high tumor burden, HAIC combined with targeted immunotherapy demonstrated significantly prolonged progression-free survival and reduced mild local adverse events compared to TACE plus targeted immunotherapy, while showing comparable overall survival and response rates.

Hao-Huan Tang, Qi Jiang, Ming-Qing Zhang, Zi-Chen Zhang, Chen Fan, Wei-Dong Wang, Shu-Shu Li, Jia-Xi Liu, Hai-Bo Shao, L (…)2026-07-01

📄 medicine

The challenge of COVID-19 on a teratogen information service in Australia

A retrospective audit of Australia's MotherSafe teratogen information service from 2019 to 2023 reveals that the COVID-19 pandemic significantly increased demand for evidence-based counseling on vaccines and medications, highlighting critical gaps in consistent public health messaging for pregnant women and clinicians.

Mitchell Baker, Penelope Fotheringham, Debra Kennedy, Delwyn Cupitt2026-07-01

📄 medicine

Bedside Ultrasound Evaluation of Gastric Emptying for Optimizing Fasting Duration in Outpatients Undergoing Sedation: A Prospective Observational Study

This prospective observational study of 199 children aged 0–6 years demonstrates that bedside ultrasound assessment of gastric emptying effectively identifies non-compliance with fasting guidelines and facilitates optimized sedation strategies to reduce the risk of pulmonary aspiration.

Fang Li, Wei Long, Jinhui Liu, Jian Zhang, Benzhen Chen2026-07-01

📄 medicine

Factors Associated with Suboptimal Adherence to Type 2 Diabetes Medications among Internally Displaced Persons in Camps in Al-Dana Subdistrict, Northwest Syria: A Cross-Sectional Study

This cross-sectional study conducted in early 2025 among internally displaced persons in Northwest Syria reveals that medication adherence for type 2 diabetes is critically low (99.1% nonadherence) and is primarily driven by structural and geographic barriers—such as distance to facilities and side effects—rather than demographic characteristics, though regular physician engagement and access to health information significantly improve adherence.

Lama Allama, Sami Najmaddin Saeed, MHD Bahaa Aldin Alhaffar, Abdulkarim Alaa Addin, Abdulmoughyth Karrat, Árpád Czifra (…)2026-07-01

📄 medicine

Associations of Multiple Environmental Pollutants with the Risk and Mortality of Viral Infectious Diseases: Differential Infection Spectrums and Trends

This study reveals that mixed environmental pollutants, particularly domestic waste, industrial wastewater, and air pollutants, significantly elevate the incidence and mortality of various viral infectious diseases in Beijing, necessitating targeted pollution control and integrated surveillance strategies to mitigate these risks.

Guolong Qu, Zhenyao Song, Weiming Hou2026-06-30

📄 medicine

Longitudinal Trajectories of Frailty and Functional Decline and Risk of Incident Stroke in Older Adults with Dysglycemia

This study of older adults with dysglycemia identifies distinct longitudinal trajectories of frailty and functional decline, revealing that the co-occurrence of high frailty and persistent instrumental activities of daily living (IADL) limitations significantly increases the risk of incident stroke.

cao chen, zeng bao wu, shun chen, ming xin zhu2026-06-30

📄 medicine

Tracking Environmental Antimicrobial Resistance: Isolation and Antimicrobial Susceptibility Patterns of E. coli across Hospital, Livestock, and Community Settings in Gampaha, Sri Lanka

This study in Gampaha, Sri Lanka, reveals that hospital and livestock environments serve as significant reservoirs for antimicrobial-resistant *E. coli*, with high rates of multidrug resistance and non-susceptibility to common antibiotics, highlighting the critical need for a One Health approach to integrate environmental surveillance and antimicrobial stewardship.

Randeni Arachchige Sachini Bhagya Randeni, Chamini Nadisha Badanasinghe, Sunil-Chandra Naranapity Pathirannahalage2026-06-30

📄 medicine

Improving Recognition of Vitamin C Deficiency in Internal Medicine: A Before–After Study of Criteria-Guided Testing in Hospitalized Adults

This before–after study conducted in a French hospital demonstrates that implementing clinical-criteria-guided testing for vitamin C deficiency in hospitalized internal medicine patients significantly increased both the frequency of testing and the diagnostic yield compared to standard clinician-directed approaches, revealing a high prevalence of previously underrecognized deficiency.

Adrian Purcarea, Rémy Bouquet, Odile Sevin, Dominique Devesa, Claudia Gavris, Silvia Sovaila2026-06-30

📄 medicine

Platelet derived small extracellular vesicles are cardioprotective in murine myocardial infarction

This study demonstrates that injecting platelet-derived small extracellular vesicles into the infarcted myocardium of mice significantly preserves cardiac function and enhances tissue revascularization, establishing them as promising therapeutic candidates for myocardial infarction.

Nathalie Tarassova, Yong Li, Jonathan A Furniss, Jordan Vautrinot, Elizabeth W Aitken, Cedric Ghevaert, Tim J A Chico, I (…)2026-06-30

📄 medicine

ED-MERGE: A Dynamic Multimodal Framework for Early Risk Stratification in the Emergency Department with External Validation

The paper introduces ED-MERGE, a dynamic multimodal framework that integrates time-aligned vital signs, structured data, and unstructured clinical notes to provide real-time, evolving risk stratification for multiple acute syndromes in the emergency department, demonstrating strong predictive performance and successful external validation.

Feng Xie, Xinrui Xiong, Xinnie Mai, Shuang Zhou, Yunqian Liu, Kai Yu, Xuhai Xu, Mingquan Lin, Rui Zhang, Michael Puskari (…)2026-06-30

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