6295 papers
This case report describes a rare instance of synchronous diffuse large B-cell lymphoma involving both the pancreas and kidney in a 43-year-old woman, which initially mimicked solid organ malignancies causing obstructive jaundice but was successfully diagnosed via biopsy and PET-CT and treated with systemic immunochemotherapy.
This systematic review of recent literature indicates that while molecular-based testing for urinary tract infections offers superior sensitivity and short-term symptom reduction compared to standard culture, the current evidence is limited by a lack of specificity, potential industry funding bias, and insufficient long-term clinical outcome data, underscoring the urgent need for further independent, multicentric studies.
This study establishes an improved, cryopreservable orthotopic breast cancer mouse model derived from MMTV-PyMT tumors that offers mass production capabilities, a broad metastatic spectrum, and low costs while revealing a TGF-β-mediated epithelial-mesenchymal transition mechanism driving metastasis.
This study develops and validates an energy-based stochastic framework that successfully reconstructs cholera dynamics in Al-Hodeidah, Yemen (2020–2024), demonstrating how environmental forcing, climatic variability, and WASH disruptions drive epidemic waves in fragile humanitarian settings.
This cross-sectional study characterizes Portugal's heterogeneous and non-standardized simulation technician workforce, revealing a critical gap between their administrative confidence and pedagogical/technical skills that necessitates a national, hands-on training program to ensure the sustainability of simulation-based education.
This retrospective study of Australian occupational healthcare data demonstrates that analyzing routine Electronic Health Record (EHR) data reveals significant variability in clinical practices and outcomes among musculoskeletal clinicians, thereby identifying actionable learning opportunities to enhance patient safety and professional development beyond traditional adverse event monitoring.
This study identifies pre-pregnancy obesity as a significant risk factor for fetal macrosomia in women with gestational diabetes, while excessive gestational weight gain is the primary risk factor for macrosomia in women with normal glucose metabolism, highlighting the need for targeted management to reduce adverse outcomes.
This pan-cancer study of 519 Indian patients reveals a 25.6% prevalence of microsatellite instability/mismatch repair deficiency, identifying a high burden of Lynch syndrome (49.6% of MSI-high/MMRd cases) driven largely by specific *MLH1* founder variants, thereby validating a tumor-first screening approach to improve detection and management across diverse cancer types in India.
This study integrates multi-omics bioinformatics and machine learning to identify SPATA18 and IGF2BP2 as robust, highly accurate diagnostic and prognostic biomarkers for Papillary Thyroid Carcinoma, elucidating their roles in key metabolic and immune pathways through a validated predictive nomogram and regulatory network.
This study evaluates the implementation of non-communicable disease care in Udupi District, India, identifying strengths in service delivery and governance while highlighting critical gaps in diagnostics, data systems, and workforce capacity, ultimately proposing a multi-sectoral approach to scale up effective NCD services.