📄 Category

medicine

6308 papers

📄 medicine

Construction of an Early Recurrence Prediction Model and Real-World Efficacy of Adjuvant Chemoimmunotherapy in High-Risk Biliary Tract Cancer

This study developed and validated a nomogram incorporating multidimensional features like LODDS and SII to predict early recurrence in high-risk biliary tract cancer, while real-world evidence demonstrated that adjuvant chemoimmunotherapy significantly reduces the risk of early postoperative recurrence compared to surgery alone or chemotherapy.

Jianguo Liao, Xinran Xie, Yin Long, Jue Huang, Lei Zhang2026-06-30
📄 medicine

TERC lncRNA in situ detection is useful in confirming cervical intraepithelial neoplasia in women with discordant histo-cytology diagnosis

This study demonstrates that TERC-FISH is a reliable biomarker for confirming cervical intraepithelial neoplasia and resolving discrepancies between histological and cytological diagnoses, as TERC amplification correlates strongly with lesion severity and high-risk HPV infection.

Youchaou Mobet, Loic P Kojom Foko, Yacouba Foupouapouognigni, Elisé Embolo EL, Zhuojun Pan, Rachisan Djiake Tihagam, Awa (…)2026-06-30
📄 medicine

Functional–behavioral patterns associated with care-related risk in hospitalized patients with Alzheimer’s disease: a real-world clustering analysis

This retrospective study of 118 hospitalized Alzheimer's disease patients utilized K-means clustering to identify three distinct functional–behavioral subtypes characterized by varying levels of impairment and symptom severity, thereby supporting the development of multidimensional risk stratification and individualized care planning.

文燕 揭, Xi Yu, Jingying Wu, Yuanyuan Xu, Caiping He, Yuting Fan, Yongjun Wang, Haiqiang Wu2026-06-30
📄 medicine

Synchronous Pancreatic and Renal Involvement by Diffuse Large B-Cell Lymphoma Presenting with Obstructive Jaundice: A Rare Extranodal Manifestation

This case report describes a rare instance of synchronous diffuse large B-cell lymphoma involving both the pancreas and kidney in a 43-year-old woman, which initially mimicked solid organ malignancies causing obstructive jaundice but was successfully diagnosed via biopsy and PET-CT and treated with systemic immunochemotherapy.

Mohammad Minakari, Hoda Imani2026-06-30
📄 medicine

Molecular Based Diagnostic Testing for Urinary Tract Infections: The Results Remain Unclear

This systematic review of recent literature indicates that while molecular-based testing for urinary tract infections offers superior sensitivity and short-term symptom reduction compared to standard culture, the current evidence is limited by a lack of specificity, potential industry funding bias, and insufficient long-term clinical outcome data, underscoring the urgent need for further independent, multicentric studies.

Meghana Reddy, Christina Sze, Bonnie Prokesch, Philippe Zimmern2026-06-30
📄 medicine

Construction of an Improved Orthotopic Transplantation Model of Breast Cancer and Study of Tumor Metastasis Mechanisms

This study establishes an improved, cryopreservable orthotopic breast cancer mouse model derived from MMTV-PyMT tumors that offers mass production capabilities, a broad metastatic spectrum, and low costs while revealing a TGF-β-mediated epithelial-mesenchymal transition mechanism driving metastasis.

Sunmian Xu, Yuyao Zhu, Xingji You, Qi Wang, Qiuxin Lu, Qian Cai, Xuexin Chen, Jingxiang Wu2026-06-30
📄 medicine

Characterization of the simulation technician profile in Portugal: a cross-sectional study

This cross-sectional study characterizes Portugal's heterogeneous and non-standardized simulation technician workforce, revealing a critical gap between their administrative confidence and pedagogical/technical skills that necessitates a national, hands-on training program to ensure the sustainability of simulation-based education.

Abel Nicolau, Elaine Gonçalves, Cristina Granja, Isabel Pereira2026-06-30
📄 medicine

Identifying Quality and Safety Learning Opportunities Through EHR Data Analytics in Musculoskeletal Practice

This retrospective study of Australian occupational healthcare data demonstrates that analyzing routine Electronic Health Record (EHR) data reveals significant variability in clinical practices and outcomes among musculoskeletal clinicians, thereby identifying actionable learning opportunities to enhance patient safety and professional development beyond traditional adverse event monitoring.

Melinda Wassell, Henry Pollard, Kerryn Butler-Henderson, Karin Verspoor2026-06-30
📄 medicine

Analysis of Risk Factors for Macrosomia in Gestational Diabetes

This study identifies pre-pregnancy obesity as a significant risk factor for fetal macrosomia in women with gestational diabetes, while excessive gestational weight gain is the primary risk factor for macrosomia in women with normal glucose metabolism, highlighting the need for targeted management to reduce adverse outcomes.

Mengting Liu, Yanmin Chen, Guanchong Li, Shuying Yang, Yan Ma, Haibo Song, Yingchun Yu, Danqing Chen2026-06-30