6308 papers
This pan-cancer study of 519 Indian patients reveals a 25.6% prevalence of microsatellite instability/mismatch repair deficiency, identifying a high burden of Lynch syndrome (49.6% of MSI-high/MMRd cases) driven largely by specific *MLH1* founder variants, thereby validating a tumor-first screening approach to improve detection and management across diverse cancer types in India.
This study integrates multi-omics bioinformatics and machine learning to identify SPATA18 and IGF2BP2 as robust, highly accurate diagnostic and prognostic biomarkers for Papillary Thyroid Carcinoma, elucidating their roles in key metabolic and immune pathways through a validated predictive nomogram and regulatory network.
This study evaluates the implementation of non-communicable disease care in Udupi District, India, identifying strengths in service delivery and governance while highlighting critical gaps in diagnostics, data systems, and workforce capacity, ultimately proposing a multi-sectoral approach to scale up effective NCD services.
This cross-sectional study of resident physicians in Southwest China reveals that while overall clinical nutrition knowledge is modest and education exposure is limited, only nutrition training received during residency (rather than medical school) is independently associated with higher knowledge scores and improved self-reported practice-related experiences.
This realist review of 17 studies proposes that adult day programs delay long-term care admissions for persons with dementia by fostering relational processes and high-quality support that empower caregivers, while highlighting the need for early, sustained access and further research into social determinants and system-level factors.
This study analyzes deep genomic sequencing data from 258 patients with metastatic or recurrent cervical cancer to reveal distinct histology-specific mutation landscapes, identify key therapeutic targets such as PIK3CA and homologous recombination repair genes, and demonstrate the clinical value of tumor mutational burden as a biomarker for immunotherapy response.
This study systematically screened thousands of phage-antibiotic combinations against clinical *E. coli* and *K. pneumoniae* isolates to identify species-specific synergistic patterns, particularly between β-lactams and Tequatroviruses, thereby establishing a foundation for rational, evidence-based therapies against multidrug-resistant urinary tract infections and urosepsis.
This study demonstrates that polyphenol-rich extracts from peach seeds exhibit significant antihyperglycemic, antioxidant, and selective antibacterial (against Gram-positive bacteria) activities in alloxan-induced diabetic rats without acute toxicity, highlighting their potential as a sustainable therapeutic source for managing diabetes and oxidative stress.
This retrospective population-based study of over 400,000 US women links individual behavioral data to claims records to identify distinct non-clinical profiles—such as concerns about side effects, cost barriers, and social support levels—that drive adherence to adjuvant endocrine therapy, suggesting that tailored interventions addressing specific behavioral combinations are needed to improve treatment outcomes.
This prospective pilot study demonstrates that augmented reality-assisted rod contouring using the ADVISE system is a feasible and safe technique for multilevel thoracolumbar pedicle screw instrumentation, resulting in significant clinical improvements and eliminating the need for forceful rod reduction maneuvers without observed implant-related complications.