6308 papers
This prospective longitudinal cohort study in Victoria, Australia, reveals that despite effective antiviral therapies, gaps in the hepatitis B care cascade—specifically low treatment uptake and missed cirrhosis diagnoses—continue to drive poor liver cancer outcomes among a significant proportion of patients.
This cross-sectional study of 1,810 people living with HIV in Machakos County, Kenya, reveals that while ART adherence is generally high, persistent HIV-related stigma and discrimination—particularly internalized stigma and healthcare-based discrimination—negatively impact treatment adherence and create complex, context-dependent dynamics regarding status disclosure, underscoring the urgent need for comprehensive, community-responsive interventions.
This paper presents a methodological framework that integrates Reflexive Thematic Analysis with Soft Systems Methodology to translate expert qualitative insights on Long-acting injectable antiretroviral therapy in South Africa into structured, actionable implementation designs, such as conceptual models and measurable indicators for complex public health systems.
This retrospective study of 160 pediatric patients with ventriculoperitoneal shunts reveals that the majority (73.1%) presenting to the emergency department had acute conditions unrelated to shunt malfunction, suggesting that routine cranial CT scans and neurosurgical consultations for all such presentations may be unnecessary and expose children to avoidable radiation.
Based on a survey of 161 adult children in China, this study reveals that while smartphone ownership is nearly universal among older adults, excessive and unbounded use creates a compound risk of physical, psychological, and social health issues that family interventions alone cannot address, necessitating a coordinated multi-stakeholder response.
This study suggests that in a real-world cohort of ER+ breast cancer patients, specific baseline gene expression profiles are associated with recurrence risk only in those treated with selective estrogen receptor modulators, whereas switching endocrine therapy is primarily driven by intolerance rather than tumor biology.
Using a 10-year longitudinal study of over 2,000 adults, this research reveals that while older adults with depression exhibit amplified affective responsivity to daily positive events compared to younger adults, this "mood brightening" effect diminishes significantly over time, particularly among the oldest participants.
In a study of sedentary middle-aged adults, elevated circulating bile acid levels were found to be associated with an adverse cardiometabolic profile and higher blood pressure, with these relationships varying by sex and partially explained by differences in body composition, particularly lean mass and visceral adiposity.
This cross-sectional study reveals that individuals with chronic low back pain exhibit rigid and fragmented muscle synergy recruitment patterns during physical tasks, which correlate with reduced performance but not pain levels, suggesting that restoring motor complexity rather than solely targeting pain is crucial for effective rehabilitation.
This study demonstrates that a cost-effective stool pooling strategy combined with PCR analysis successfully identified a higher-than-expected prevalence of Strongyloides in Ghanaian communities, highlighting the need for sensitive diagnostics to guide targeted public health interventions.