3171 papers
This study demonstrates through prospective cohort and integrative genetic analyses that elevated serum gamma-glutamyl transferase (GGT) levels are significantly associated with an increased risk of frailty, mediated by metabolic, immune, and vascular pathways, suggesting GGT as a promising biomarker for identifying individuals at high risk.
This nationwide cohort study of Chinese middle-aged and older adults demonstrates that both higher cumulative exposure to and persistently high dynamic trajectories of the C-reactive protein-triglyceride-glucose index (CTI) are significantly associated with an increased risk of developing Cardiovascular-Kidney-Metabolic (CKM) syndrome stage 4.
A multicenter study of 1,005 Nigerian medical students reveals a high prevalence of psychological distress (81.3%) alongside critically low utilization of mental health services (9.3%), primarily driven by stigma and confidentiality concerns despite widespread willingness to seek help.
This cross-sectional study of 401 women in Damascus hospitals reveals that obesity, PCOS, diabetes mellitus, and tobacco exposure are significantly associated with delayed conception, underscoring the need for integrated screening and lifestyle interventions in Syrian fertility care.
This comparative randomized mixed-methods study demonstrates that both Design Thinking and Focus Groups are effective methods for engaging Hispanic and Latino stakeholders in autism research, with Design Thinking offering distinct advantages in fostering mutual learning and co-developing actionable solutions.
This study of 37 boys with Duchenne muscular dystrophy found that while cognitive functioning is independent of mutation location and ambulatory status, health-related quality of life is significantly lower in non-ambulatory patients, highlighting the need for multidisciplinary care to address functional limitations.
This study utilizes plasma lipidomics to identify specific lipid biomarkers, particularly LysoPC(16:0) and a four-lipid panel, which effectively predict recurrent ischemic stroke risk and reveal dysregulated glycerophospholipid and fatty acid metabolic pathways underlying the disease.
A 2024 cross-sectional survey in Uganda reveals that the national coverage of the second dose of the measles–rubella vaccine remains critically low at 32.0%, driven by significant regional disparities and influenced by factors such as birth order, household composition, age, and caregiver experiences with vaccine safety and service quality.
This qualitative study demonstrates that implementing a cross-organisational oral health randomised controlled trial in Swedish home care is feasible but critically depends on substantial organisational readiness, clear cross-sector coordination, and the adaptive strategies employed by frontline staff to navigate structural ambiguities and complex workflows.
This study evaluates the socio-technical barriers to Electronic Health Record implementation at a tertiary hospital in Iran, revealing that despite high user satisfaction and acceptance, inadequate training and organizational readiness remain the primary obstacles to successful deployment.