📄 Category

medicine

6308 papers

📄 medicine

Efficacy Evaluation and Pharmacological Mechanism Exploration of Polyporus umbellatus (Pers.) Fries in Hepatitis E Virus Treatment: A Combined Study of Meta-Analysis, Network Pharmacology, and Molecular Docking

This study integrates meta-analysis, network pharmacology, and molecular docking to demonstrate that *Polyporus umbellatus* effectively alleviates hepatitis E virus-induced liver damage by modulating specific bioactive compounds, molecular targets, and signaling pathways, thereby providing a scientific basis for its clinical translation.

Zhenwen He, Dingyu Liu, Qin Luo, Baoling Liu, Dongqi Chen, Hua Xiang, Xiaohu Wang, Gang Wang, Yuan Huang, Jing C Chen, R (…)2026-06-29
📄 medicine

Assessment of the Adoption of Healthcare Waste Management Policies in Government Primary Health Facilities in Ibadan, Nigeria

This study reveals that while healthcare workers in government primary health facilities in Ibadan, Nigeria, demonstrate some awareness of waste segregation, the adoption of national healthcare waste management policies remains incomplete and inconsistent due to critical gaps in training, infrastructure, funding, and the availability of essential materials and safety protocols.

Esther Okoko, David A. Adewole2026-06-29
📄 medicine

Impact of Spleen Size on Perioperative Outcomes After Laparoscopic Splenectomy: A Single-Center Retrospective Cohort Study

This single-center retrospective study of 63 patients demonstrates that a preoperative spleen size of 150 mm or greater is an independent predictor of increased postoperative morbidity following laparoscopic splenectomy, suggesting its utility as a key risk stratification parameter for surgical planning.

hamdi burak piyade, murat derebey, ismail alper tarım, ufuk karabacak, ayfer kamalı polat2026-06-29
📄 medicine

A case report on malignant phyllodes tumour with bone metastasis demonstrating DNA damage response and organoid guided sensitivity to doxorubicin

This case report describes a patient with metastatic malignant phyllodes tumour whose patient-derived organoids demonstrated selective sensitivity to doxorubicin, supported by extensive DNA damage response markers, highlighting the potential of ex vivo organoid testing as a precision medicine tool for guiding treatment in rare breast neoplasms.

Selwin Gabriel Samuel, Tirsa van Wyngaard, Penny L Jeffery, Abby Templeton, Lisa Philp, Sophie Napier, Anthony Atack, Ke (…)2026-06-29
📄 medicine

Barriers for Coverage of Iron and Folic Acid Supplementation among Under-Five Children in Rural Area of Kodagu District, India: A Mixed Method Study

This mixed-method study in rural Kodagu, India, reveals critically low Iron and Folic Acid supplementation coverage (0.5% current, 12.9% ever) among children aged 6–59 months, attributing the failure to systemic barriers including inadequate health worker training, supply shortages, poor community awareness, and parental safety concerns.

Krishma N K, Mackwin Kenwood Dmello, Neevan Dsouza2026-06-29
📄 medicine

Extended-release calcifediol for secondary hyperparathyroidism in Chinese adults with stage 3 or 4 chronic kidney disease: a randomized trial

This randomized controlled trial demonstrates that extended-release calcifediol is a well-tolerated and effective treatment for reducing secondary hyperparathyroidism and correcting vitamin D insufficiency in Chinese adults with stage 3–4 chronic kidney disease.

Ming Fang, Yan Hao, Huijuan Mao, Hong Ren, Xiaohui Liao, Xiaowei Li, Yinan Li, Hongyan Tian, Haiming Li, John Choe, Akht (…)2026-06-29
📄 medicine

Comparison of the Predictive Value of TyG, TyHGB, and TyG-AIP for the Risk of Acute ST-Segment Elevation Myocardial Infarction and In-Hospital Major Adverse Cardiovascular Events

This retrospective study of 1,000 patients demonstrates that the TyHGB index outperforms TyG and TyG-AIP as a superior biomarker for predicting the onset, severity, and in-hospital adverse outcomes of ST-segment elevation myocardial infarction, particularly due to its robust linear association with major adverse cardiovascular events.

Xiang Wen, Ruiqing Cui, Qiaoyun Ou, Li Yang, Xueya Li, Zhang Jing2026-06-29
📄 medicine

Metabolic syndrome in patients receiving glucocorticoid replacement for primary adrenal insufficiency

This cross-sectional study of 239 patients with primary adrenal insufficiency found that while metabolic disorders are common, the overall frequency of metabolic syndrome is not significantly elevated compared to the general population, except among post-menopausal women, and is not directly linked to daily hydrocortisone dosage when administered within recommended ranges.

Marta Fichna, Anita Rogowicz-Frontczak, Hanna Komarowska, Piotr Fichna, Anna Sowinska, Marek Ruchala2026-06-29
📄 medicine

Explaining ‘medically unexplained’ symptoms: student perceptions of teaching at the University of Auckland

A survey of final-year medical students at the University of Auckland reveals that despite perceiving medically unexplained physical symptoms as common and impairing, most feel inadequately trained in their recognition and management, highlighting a critical need for enhanced interdisciplinary education on biopsychosocial models and communication skills.

Nancy Huang, Frederick Sundram, David Benjamin Menkes2026-06-29