📄 medicine

Effectiveness of a Contextually Tailored E-Learning Module in Improving Colorectal Cancer Screening Knowledge and Practice Among Primary Care Physicians in Malaysia: A Pre-Post Interventional Study

A pre-post interventional study involving 110 primary care physicians in Kuching, Sarawak, demonstrated that a contextually tailored e-learning module significantly improved colorectal cancer screening knowledge and clinical reasoning, though systemic barriers such as time constraints and limited clinic infrastructure continue to hinder the consistent translation of this knowledge into clinical practice.

Snehlata Prashant Samberkar, Retnagowri Rajandram, Jason Yang Chern Khaw, Mohamed Rezal Abdul Aziz2026-06-29
📄 medicine

The Impact of Recovery Achievement on the Value of Post-Tube Chest X-Ray After Chest Tube Removal Following Robotic Lung Resection

This retrospective study of 502 robotic lung resection patients demonstrates that while post-chest tube removal X-rays are beneficial for identifying complications in patients with targeted or delayed recovery, they can be safely omitted for those achieving accelerated recovery on postoperative day one.

Arham Aslam, Madison Harrison, Yoichiro Shimada, Christina Jander PAC, Madhan Kuppusamy, Joel Sternbach, Michal Hubka2026-06-29
📄 medicine

Intracranial Atherosclerosis in Corticobasal Degeneration: A Neuropathological Study of a Case Series

This neuropathological study of eight corticobasal degeneration cases reveals that intracranial atherosclerosis, particularly in large-caliber arteries of the Circle of Willis, is a common pathological finding characterized by stable plaques, suggesting a potential link to neuroinflammatory mechanisms that warrants further investigation.

Leonardo Caixeta, Wesley Gomes Silva, Yanley Lúcio Nogueira, Victor Caixeta, Liberato Almeida, Gabriel Pullig Prado, Cir (…)2026-06-29
📄 medicine

Comparative Effectiveness of Telemedicine Versus In-Person Consultation in Saudi Primary Healthcare: A Systematic Review

This systematic review of six Saudi Arabian studies concludes that telemedicine in primary healthcare serves as a useful complementary model to in-person care, demonstrating comparable patient satisfaction and chronic disease management outcomes, though the current evidence base is limited by observational designs and a need for more robust prospective research.

Raneem Saleh, Norah Albishr, Maram Almutairi, Abdulrhman Alkthiry2026-06-29
📄 medicine

Efficacy and safety of first-line systemic therapies for patients with metastatic triple negative breast cancer ineligible for anti-PD-(L)1 inhibitors in clinical practice: a systematic review and network meta-analysis

This systematic review and network meta-analysis of 10 randomized controlled trials involving 3,752 patients indicates that for first-line treatment of metastatic triple-negative breast cancer in patients ineligible for anti-PD-(L)1 inhibitors, antibody-drug conjugates (specifically datopotamab-deruxtecan and sacituzumab-govitecan) and bevacizumab plus chemotherapy significantly improve progression-free survival compared to chemotherapy alone, while PARP inhibitors remain the preferred option for patients with germline BRCA1/2 mutations.

Aldo Caltavituro, Giuseppe Di Grazia, Anna Aguilera, Roberto Buonaiuto, Jacopo Canzian, Marcin Kubeczko, Giuseppe Buono (…)2026-06-29
📄 medicine

Integrated Cytokine Network Profiling Reveals Synergistic Inflammatory Clusters Associated with PASI Severity in Psoriasis

This study demonstrates that psoriasis severity is driven by a synergistic network of pro-inflammatory cytokines (specifically IL-17A, IL-22, and TNF-α) rather than isolated mediators, and identifies IL-22 and IL-12(p40) as potential biomarkers for monitoring treatment response.

Vanda Bondare-Ansberga, Peteris Tretjakovs, Simons Svirskis, Antra Jurka, Indra Mikelsone, Normunds Limba, Leons Blumfel (…)2026-06-29
📄 medicine

Assessment of Patient Safety Culture in Community Pharmacies Using the Pharmacy Survey on Patient Safety Culture (Pharmacy SOPS)

A 2025 cross-sectional study of 350 pharmacy staff in Herat, Afghanistan, utilizing the validated Pharmacy SOPS instrument, revealed a moderate-to-high overall patient safety culture score with notable strengths in counseling but significant challenges related to staffing and workload, which were further influenced by staff age and experience.

sara jamili, fatemeh kokabisaghi, Safielah Ishaqzai, Hosein Ebrahimipour2026-06-29