6308 papers
This hospital-based study of 100 patients reveals that lumbar Modic degenerative endplate changes, particularly Type II, are significantly associated with functional disability, higher body mass index, and reduced intervertebral disc height.
Mogrol protects against hepatic ischemia–reperfusion injury by preserving mitochondrial function and mitigating oxidative stress and inflammation through the activation of the PI3K/AKT signaling pathway.
Although Niosome-encapsulated Rapamycin demonstrated promising physicochemical stability and comparable in vitro efficacy against Leishmania major amastigotes to the standard drug Glucantime, its topical application failed to reduce lesion sizes in a murine model, highlighting that systemic delivery remains superior for treating leishmaniasis due to the limitations of topical drug penetration.
This ten-year retrospective cohort study in Abidjan, Côte d'Ivoire, reveals that extrapulmonary tuberculosis is highly lethal among HIV-infected adults, with mortality rates reaching 58% for tuberculous meningitis and peaking within the first two months of treatment, while identifying cotrimoxazole prophylaxis and higher CD4 counts as significant protective factors.
This in vitro study found no statistically significant difference in apical microleakage between Calcium-Enriched Mixture (CEM) Cement and Cold Ceramic when used as root-end filling materials, indicating comparable sealing performance for both.
This retrospective study of 322 bariatric surgery patients in Qatar demonstrates that intraoperative clonidine administration significantly improves postoperative recovery by reducing pain scores, opioid consumption, and PACU stay while enhancing hemodynamic stability, despite a higher incidence of manageable bradycardia.
This retrospective study of the German Statutory Accident Insurance system reveals a significant rise in cruciate ligament injuries among young individuals from 2010 to 2020, resulting in prolonged work disability and substantial lifetime costs averaging over €209,000 per case.
This study validates a multimodal endoscopic system integrating near-infrared autofluorescence and laser speckle contrast imaging with pseudo-color visualization, demonstrating its ability to accurately localize parathyroid glands and provide real-time, label-free perfusion assessment in a preclinical rat model to guide intraoperative preservation decisions.
This retrospective study demonstrates that machine learning models, particularly Random Forest, trained on routine admission data can achieve high negative predictive values (≥95%) for endoscopically confirmed active upper gastrointestinal bleeding, offering a potential tool to improve specificity and reduce unnecessary endoscopies in emergency department patients.
Based on a 2024 multisite study of 6,770 Chinese older adults, higher sleep regularity is significantly associated with reduced multidimensional health loss across various metrics, an effect that is more pronounced among robust and prefrail individuals than among those who are already frail.