6308 papers
This retrospective study of 70 MRONJ patients highlights that *Actinomyces* colonization occurs in 30% of cases, is significantly associated with specific oncological diagnoses like breast cancer, and responds well to combined surgical and targeted antibiotic therapy, supporting its consideration in multidisciplinary treatment planning.
This paper defines and validates a series of seven electronic phenotypes using real-world EHR data to enable scalable, reliable, and retrospective measurement of adherence to the Wake Up and Breathe protocol for mechanically ventilated ICU patients, demonstrating moderate to near-perfect agreement with manual chart review.
This study utilizes network analysis of baseline data from the Sydney Memory and Ageing Study to reveal that individuals who develop dementia exhibit distinct biomarker connectivity patterns, such as the loss of cognition-age links and the emergence of mood-metabolic connections, years before clinical diagnosis.
Despite near-universal knowledge of exclusive breastfeeding benefits, healthcare providers in Kigali, Rwanda, exhibit a significant knowledge-practice gap characterized by low exclusive breastfeeding rates and high mixed feeding, primarily driven by workplace barriers such as lack of time, inadequate support, and insufficient institutional policies.
This study reports a pediatric case of hereditary distal renal tubular acidosis caused by a homozygous SLC4A1 p.G701D variant, characterized by recurrent hypokalemia and severe skeletal deformities, and highlights the importance of early genetic diagnosis and longitudinal follow-up for optimizing clinical management.
This paper presents a validated in silico Phase I trial framework that integrates human-calibrated cardiomyocyte populations, ion-channel blocking, tissue-level propagation, and physiological fibrosis to accurately predict drug-induced QT prolongation and inter-individual variability, demonstrating that including low-degree tissue heterogeneity is essential for achieving high concordance with clinical safety data.
This multicenter registry study utilized machine learning to identify pathological N stage, threatened mesorectal fascia on preoperative MRI, and intersphincteric resection as key factors associated with positive circumferential resection margins following transanal total mesorectal excision, while noting that the resulting models require further preoperative-focused validation before clinical application.
The BELIEVE study found that strict vegetarian women aged 20–35 exhibit significantly lower bone mineral density and higher bone turnover compared to omnivores, primarily driven by inadequate intakes of calcium, protein, and vitamin D during peak bone mass acquisition.
This study utilizes data from two nationwide prospective cohorts (CHARLS and ELSA) to demonstrate that the C-reactive protein-triglyceride-glucose index (CTI) is a robust, independent predictor of both incident frailty and accelerated frailty progression in older adults, highlighting the critical role of combined metabolic and inflammatory dysregulation in physiological decline.
This prospective cohort study demonstrates that concordant high levels of tuberculosis infection control knowledge in both pulmonary TB patients and their household contacts are significantly associated with improved treatment adherence, suggesting that family-based health education is a promising strategy to strengthen TB control efforts.