📄 medicine

Comparative Clinical Efficacy and Safety of Botulinum Toxin Type A and Type B in Cosmetic and Medical Applications: A Cross-Sectional Study

This cross-sectional study of 126 patients found no statistically significant differences in efficacy, safety, or patient satisfaction between Botulinum Toxin Type A and Type B across various cosmetic and medical indications, suggesting that clinical choice should be guided by context and availability rather than expected performance disparities.

Sdra Bassam Alsaloum Alibrahim, Belal Giath Meshaal, Asia Safouh Sawwan, Haidar Yousef2026-06-29
📄 medicine

Feasibility of Diffuse Reflectance Spectroscopy for Distal Margin Assessment in Colorectal Cancer Surgery

This study demonstrates the feasibility of using broadband diffuse reflectance spectroscopy combined with machine learning to accurately distinguish between tumor and healthy tissue in colorectal cancer specimens, achieving high sensitivity and specificity for potential intra-operative distal margin assessment.

Joris T. Hepkema, Isis Boeije, Arend G.J. Aalbers, Brechtje A. Grotenhuis, Marinke Westerterp, Freija Geldof, Behdad Das (…)2026-06-29
📄 medicine

Multimodal Machine Learning Model Integrating Preoperative Contrast-Enhanced CT Radiomics and Clinicopathological Features for Predicting Early Extrahepatic Recurrence After Hepatectomy of Hepatocellular Carcinoma

This study developed and validated a Random Forest-based multimodal machine learning model integrating preoperative CT radiomics and clinicopathological features to accurately predict early extrahepatic recurrence in hepatocellular carcinoma patients following hepatectomy, achieving an AUC of 0.836 in external validation and enabling effective risk stratification for personalized postoperative management.

Yanze Li, Xiaolong Luo, Qilin Li, Yanwei Wang, Jiazhi Zhang, Yi Li, Bo Li, Kangyi Jiang, Xiaoli Yang2026-06-29
📄 medicine

Intra-rater within-session and inter-rater reliability of MyotonPRO® and IndentoPRO for assessing abdominal wall viscoelastic and biomechanical properties in late postpartum women

This study demonstrates that both the MyotonPRO® and IndentoPRO devices exhibit acceptable intra- and inter-rater reliability for assessing abdominal wall viscoelastic and biomechanical properties in late postpartum women, with the MyotonPRO® showing superior consistency between raters and potential utility for clinical and research applications in postpartum rehabilitation.

Luiza Z. Fanti, Fabiana C. Silva, Chiara M. Vasconcelos, Robert Schleip, Renata Salomão, Ronaldo H. Cruvinel-Júnior, Mar (…)2026-06-29
📄 medicine

Metformin-associated lactic acidosis in patients with CKD with control of metformin dosage based on renal function: A case report and review of literature

This case report and literature review demonstrate that metformin-associated lactic acidosis can occur in chronic kidney disease patients even with appropriate renal-based dosing, highlighting the need for clinical vigilance, prompt discontinuation during illness, and the potential utility of continuous hemodiafiltration for treatment.

Hideyuki Yamada, Hideyo Oguchi, Shintaro Ochiai, Kenji Nakata, Ken Sakai2026-06-29
📄 medicine

A Clinical Spectrum of Antisynthetase Antibody Positivity in a Non-preselected General Hospital Population

This study of a non-preselected general hospital population reveals that antisynthetase antibody positivity exhibits significant phenotypic heterogeneity with substantial diagnostic variability across criteria, where only a minority of patients present with prototypic antisynthetase syndrome features despite high rates of interstitial lung disease, inflammatory arthritis, and elevated mortality compared to the general population.

Danny Kasto, Michael McLucas, Brooke Gardiner, Anne-Marie Aubin, Armando Faigl, Gabor Major2026-06-29
📄 medicine

Management and 1-year outcomes of first-episode venous thromboembolism in patients over 75: a prospective observational study

In a prospective observational study of patients over 75 with first-episode venous thromboembolism, discontinuing anticoagulation after the acute phase was associated with significantly reduced bleeding and composite adverse outcomes without increasing the risk of recurrence or mortality, supporting an individualized approach to treatment duration in the elderly.

Davide Ceccato, Giacomo Turatti, Francesca Boscaro, Anna Poretto, Francesca Curri, Giampiero Avruscio, Paolo Prandoni2026-06-29
📄 medicine

Region-specific QCT thresholds for osteoporosis assessment in the thoracic spine: why lumbar cut-offs fail

This study demonstrates that established lumbar QCT thresholds are not directly transferable to the thoracic spine due to significant anatomical and biomechanical differences, necessitating the use of newly derived, region-specific cut-offs to prevent systematic misclassification of osteoporosis and improve surgical decision-making.

Friederike S. Klockner, Katharina Jäckle, Hassan Awan Malik, Jonathan Roch, Marc-Pascal Meier, Wolfgang Lehmann, Lukas W (…)2026-06-29
📄 medicine

Effectiveness of a novel mobile health application in educating first time complete denture wearers: a prospective clinical study

This prospective clinical study found that while a novel mobile health application significantly improved denture care knowledge and was highly accepted among first-time complete denture wearers compared to conventional education, it did not result in a statistically significant reduction in denture plaque accumulation after three months.

Aditi Sooda, Vidya K Shenoy, Basappa B Kodada, Aneesh Bhat, shobha J Rodrigues, Kailashchandra Shenoy K2026-06-28
📄 medicine

Venous Infarction Mimicking Brain Tumor: Recognition of the Sulcal Tram-Track Sign and Gyriform Diffusion restriction

This study highlights that venous infarctions caused by cortical vein thrombosis can mimic intracranial tumors on MRI, but their diagnosis can be facilitated by recognizing the distinctive "Sulcal Tram-Track Sign" on T2-weighted imaging, along with associated gyriform diffusion restriction and susceptibility findings, thereby preventing unnecessary invasive procedures.

Nishtha Yadav, Mohit Pal, Ketan Hedaoo, Anjali Chouksey, Vijay Singh Parihar, Shailendra Ratre, Namrata Khandelwal, Jiti (…)2026-06-28