6308 papers
This double-blind, randomized crossover study demonstrates that acute nicotine exposure via e-cigarettes significantly enhances endothelium-dependent vasodilation in healthy male sporadic tobacco users, a response likely mediated by nicotinic acetylcholine receptors that may represent an early pathological adaptation rather than a protective effect.
This prospective observational study from Eastern India demonstrates that while non-bronchoscopic methods provide an initial diagnosis in 40% of non-resolving pneumonia cases, bronchoscopy significantly increases the overall diagnostic yield to 66.2% by identifying additional malignancies and fungal infections in patients with inconclusive initial evaluations.
This prospective study demonstrates that high-frequency ultrasonography effectively detects progressive cutaneous and subcutaneous structural changes in chronic venous disease, with findings that significantly correlate with the clinical severity defined by the CEAP classification.
This cross-sectional study in Shanghai found that patients with chronic diseases attending integrated specialist–generalist outpatient clinics reported significantly better primary care experiences compared to those in general outpatient clinics, suggesting this model effectively enhances chronic disease management.
This retrospective cohort study utilizing the MIMIC-IV and eICU databases reveals that higher early postoperative fraction of inspired oxygen (FiO₂) exposure is significantly associated with an increased risk of pulmonary complications in patients undergoing coronary artery bypass grafting, supporting the need for individualized oxygen titration to avoid unnecessary high FiO₂ levels.
This study demonstrates that circulating immune biomarkers, particularly soluble immune checkpoints and cytokines, reflect an immune imbalance in pulmonary tuberculosis patients and that a derived Immune Imbalance Score (IIS) effectively predicts disease severity and poor prognosis.
This retrospective study reveals that patients with thoracolumbar ossification of the ligamentum flavum (TLOLF) concomitant with Scheuermann's disease exhibit greater thoracolumbar kyphosis, a shorter symptom duration, and superior postoperative neurological recovery compared to those without the condition, suggesting that the associated kyphosis may accelerate ossification and improve surgical prognosis.
This retrospective study utilizing Japanese insurance claims data from 2016 to 2022 reveals that while essential tremor prevalence is rising among the elderly, treatment rates remain low with limited use of first-line beta-blockers, suggesting potential undertreatment and highlighting the condition's significant role in escalating healthcare costs for Japan's aging population.
This nationally representative cohort study of U.S. adults with early-stage cardio-kidney-metabolic syndrome reveals that higher HALP scores are significantly associated with reduced all-cause mortality through a nonlinear, L-shaped relationship, where the protective effect plateaus at a threshold of approximately 48.8.
This prospective study demonstrates that analyzing circulating cell-free DNA fragmentomics, specifically shorter fragment lengths and higher concentrations, can effectively distinguish pancreatic ductal adenocarcinoma from chronic pancreatitis and healthy controls, offering a promising minimally invasive diagnostic approach.