6308 papers
This single-centre retrospective study of 93 patients demonstrates that a circumferential intraluminal thrombus distribution pattern is an independent predictor of abdominal aortic aneurysm rupture, significantly improving risk stratification beyond conventional parameters like maximum transverse diameter.
This nationwide Japanese cohort study characterizes the unique landscape of castration modalities, PSA suppression levels at treatment initiation, and the rising epidemiology of cardiovascular events among men with prostate cancer from 2010 to 2024, highlighting distinct clinical patterns compared to Western practices.
This study demonstrates that percutaneous microscopic lumbar discectomy via the trans-superior ligamentum flavum boundary approach is a safe and effective treatment for highly upward-migrated lumbar disc herniation, utilizing the superior border of the ligamentum flavum as a reliable landmark to achieve precise fragment removal with minimal fluoroscopy and favorable long-term clinical outcomes.
This case report describes a 14-year-old male with aggressive, post-biopsy cranial Langerhans cell histiocytosis who achieved rapid clinical and radiological improvement following minimally invasive intralesional and perilesional triamcinolone injections, suggesting this approach as a viable therapeutic alternative for cases with limited surgical options.
This study found that while immune-metabolic indices like the lactate-to-albumin ratio demonstrate prognostic performance comparable to established severity scores for predicting 28-day mortality in children requiring continuous kidney replacement therapy for acute kidney injury, they do not provide independent predictive value beyond these existing scores.
This cross-sectional analysis of 873 phase I systemic therapy trials reveals that while the inclusion of patients with brain metastases has improved over time—particularly for immunotherapy and targeted therapy trials—restrictive eligibility criteria frequently exclude those with symptomatic, active, or untreated brain metastases.
This 10-year analysis of Aesthetic Society-endorsed fellowship graduates reveals that the majority transition into private practice, often starting in group settings before moving to solo practice, while those pursuing academic careers demonstrate significantly higher research productivity.
This prospective cohort study of 360 critically ill children reveals that early fluid overload is a dose-dependent, modifiable risk factor for acute kidney injury and prolonged intensive care, but it does not independently increase mortality once illness severity and the development of AKI are accounted for.
This case report demonstrates the critical diagnostic value of integrating transthoracic echocardiography, coronary computed tomography angiography, cardiac magnetic resonance, and coronary angiography to comprehensively characterize a rare case of multiple giant coronary artery aneurysms with massive mural thrombosis, thereby guiding risk stratification and treatment planning.
In a naturalistic therapeutic drug monitoring study of 305 samples, the proportion of active S-citalopram in plasma was found to increase with patient age and decrease with the time elapsed since dose intake, while sex and dosage had no significant impact.