6308 papers
This case report describes the successful management of a toddler with DEAP-HUS, initially misdiagnosed as STEC-associated HUS, using eculizumab and mycophenolate mofetil without corticosteroids, which allowed for the safe discontinuation of complement blockade while maintaining clinical stability.
This retrospective ecological study in Kampala (2021–2024) utilized spatio-temporal generalized additive models to reveal significant spatial clustering of respiratory diseases in specific city divisions and distinct seasonal patterns, identifying PM2.5 as a key modifiable risk factor.
This study of 285,338 UK Biobank participants demonstrates that long-term, low-concentration ambient benzene exposure is dose-responsively associated with an increased risk of incident chronic obstructive pulmonary disease (COPD), with this risk significantly amplified by additive interactions involving biological aging, shortened telomeres, smoking, and high genetic susceptibility.
This study demonstrates that surgical resection for progressive brain metastases following prior irradiation offers significant diagnostic, therapeutic, and prognostic value by accurately distinguishing tumor recurrence from radiation necrosis, providing immediate symptomatic relief and steroid withdrawal regardless of pathology, and revealing that radiation necrosis is associated with improved overall survival.
This study of 100 female Hodgkin lymphoma survivors in southern Italy treated with non-pegylated liposomal doxorubicin found no cases of breast cancer after a median 10-year follow-up, suggesting that this specific formulation may not carry the same increased breast cancer risk as conventional doxorubicin in young adult and adult patients.
This study demonstrates that Long COVID constitutes a clinically homogeneous physio-affective phenome characterized by intercorrelated affective, fatigue, respiratory, and neurological symptoms, which are strongly predicted by the severity of acute infection markers and specific biomarkers indicating reduced antioxidant capacity, nitric oxide, and alanine transaminase levels.
This single-center Brazilian study demonstrates that open microsurgical brainstem biopsy through safe entry zones is a safe and effective procedure for children with suspected diffuse intrinsic pontine glioma, achieving 100% tissue yield with no permanent morbidity and providing crucial molecular stratification that guides clinical management.
This study identifies Annexin A2 (ANXA2) as a critical mediator of bevacizumab resistance and tumor infiltration in glioblastoma, demonstrating that high ANXA2 expression predicts poor patient survival and serves as a promising biomarker and therapeutic target to overcome adaptive resistance.
This machine-learning study of over 60,000 tuberculosis patients in southwestern China demonstrates that fine-scale geographic accessibility metrics significantly improve the prediction of delayed entry into designated care, suggesting that effective delay-reduction policies must integrate dynamic transport and urban planning with health-service redesign.
This study introduces the InSilico-K digital twin platform, a computational framework that simulates neoadjuvant therapies and tumor biophysics to predict pathological complete response rates and support a paradigm shift toward minimal "Adjuvant Surgery" for early-stage EGFR-mutated non-small cell lung cancer.