📄 medicine

Evaluation of Substitution of Total Bilirubin by Direct Bilirubin in Prediction of Mortality Models in patients with acute and Acute-on-chronic liver failure

This prospective observational study demonstrates that substituting total bilirubin with direct bilirubin in mortality prediction models (such as AARC, MELD, and MELD-Na) significantly enhances prognostic accuracy for patients with acute-on-chronic liver failure and offers comparable benefits for those with acute liver failure.

Hanaa Badran, Maha Elsabaawy, Samar Ghanem, Sania Yahia, Mahmoud Mansour, Marwa Elfayoumy2026-06-28
📄 medicine

Application of Total Bilirubin to Albumin Ratio in Predicting In-Hospital Mortality of Acute Pancreatitis and Construction and Validation of Machine Learning Prediction Models: A Multi-Database Study

This multi-database study demonstrates that the total bilirubin to albumin ratio (TBAR) is an independent risk factor for in-hospital mortality in acute pancreatitis patients and that a support vector machine model integrating TBAR, age, and SOFA score provides optimal predictive performance.

Rui Zhang, Zheng Xu, Hongwei Li, Qi Han, Guosheng Wang2026-06-28
📄 medicine

Retrospective comparison of total ankle arthroplasty with patient-specific instrumentation and ankle arthrodesis for patients with end-stage ankle arthritis and preoperative degeneration of adjacent joints

This retrospective study demonstrates that total ankle arthroplasty with patient-specific instrumentation yields superior functional outcomes and preserves ankle motion compared to ankle arthrodesis in patients with end-stage ankle arthritis and preoperative adjacent joint degeneration, without increasing complication rates or accelerating peritalar joint progression at short-term follow-up.

Mingxin Shi, Liang Cui, Lei Zhao, Shiwu Tao, Fengming Feng, Wang Zhang, Zongyu Yang2026-06-28
📄 medicine

Cross-cultural adaptation and psychometric evaluation of the Tamil Version of the Central Sensitization Inventory (CSI-Tamil)

This study successfully developed and validated the Tamil version of the Central Sensitization Inventory (CSI-Tamil) for use in Tamil-speaking populations, demonstrating that the adapted tool possesses good internal consistency, acceptable test-retest reliability, and strong validity for assessing central sensitization symptoms in patients with chronic musculoskeletal conditions.

Veeragoudhaman T.S, Thangamani Ramalingam Alagappan, Mariyam Farzana S.F, Sowmiya Meganathan, Jothi Prasanna K, Vinitha (…)2026-06-28
📄 medicine

Persistent Emergency Department Burden for High-Specificity Head Injury Phenotypes in Children Younger Than 2 Years Despite Rapid Birth-Cohort Contraction: A Nationwide Population-Based Trend Study in South Korea, 2016–2023

Despite a 44% decline in South Korea's under-2 population from 2016 to 2023, the emergency department burden for high-specificity pediatric head injuries remained stable, resulting in a significantly increased incidence rate and challenging the assumption that injury surveillance needs will proportionally decrease with shrinking birth cohorts.

Jeeho Han, Jisun Shin, Seong Il Ryu2026-06-28
📄 medicine

Impact of Creating Awareness on First 1000 Days of Life Among Prenatal Tribal Women in Attappady, Kerala: A Community- Based Pre–Post Interventional Study

This community-based pre–post interventional study in Attappady, Kerala, demonstrates that a culturally sensitive, multi-modal nutrition education program significantly improved knowledge across 16 domains among 365 pregnant tribal women, addressing critical nutritional gaps and highlighting the need for experiential methodologies in maternal health programs for indigenous populations.

D Sridevi, K. Navya Ganga, B. Kanishka, G. Latha2026-06-28
📄 medicine

Analysis of Differences in the Effects of Smoking on Variaous Semen Parameters: A Multivariable Propensity Score Matching Study

This multivariable propensity score matching study of 1,355 males in Xinjiang demonstrates that smoking significantly reduces sperm concentration and total sperm count but does not significantly affect progressive motility or sperm viability, indicating a primary negative impact on sperm quantity rather than quality.

Yasen Qimanguli, Xueyu Wei, Jumanali Mireyi, Jun Liu, Lijuan He2026-06-28
📄 medicine

The Experiences of Pregnant Women with Early-Onset Preeclampsia in Qatar: A Qualitative Descriptive Study

This qualitative descriptive study explores the experiences of ten pregnant women in Qatar diagnosed with early-onset preeclampsia, revealing seven key themes regarding their coping mechanisms, symptom management, and care needs to inform more effective nursing and midwifery support.

Lina Nasser AlYazidi, Deborah White, Carla Ginn, Shannan MacNevin, Behrokh Nikaiin, John Paul Ben Silang, Daniel Forgrav (…)2026-06-28