📄 Category

medicine

6727 papers

📄 medicine

Clinical characteristics and risk factors in dry eye disease secondary to chronic graft-versus-host: A Comparative Cross-Sectional Study

This comparative cross-sectional study reveals that dry eye disease secondary to chronic graft-versus-host disease exhibits more severe ocular surface damage, meibomian gland loss, and degraded visual quality than non-cGVHD dry eye, with specific transplant-related factors such as acute myeloid leukemia and haploidentical HLA matching serving as significant predictors of severity.

Danna Chen, Shitong Huang, Jinyu Zhang, Jinqi Huang, Yu Jiang, Caihong Pang, Simin Wen, Honghua He, Yanhua Pang, Yunxia (…)2026-06-28
📄 medicine

Reclassification of Variants of Uncertain Significance in BRCA1, BRCA2, and PALB2: Implications for Clinical Decision-Making in Breast Cancer

This retrospective study of 6,369 breast cancer patients demonstrates that while the reclassification rate of Variants of Uncertain Significance (VUS) in BRCA1, BRCA2, and PALB2 is low (3%), the process significantly impacts clinical decision-making by resolving uncertainty and guiding therapeutic strategies.

Angeliki Meintani, Dimitra Bouzarelou, Romina Alevizou, Charalampos Vitsas, Christos Vrekas, Anna Giannopoulou, Styliani (…)2026-06-28
📄 medicine

The Efficacy of Automated Breast Ultrasound Combined with Hand-held Ultrasound in Evaluating MRI-Detected High-Risk Non-Mass Lesions

This study demonstrates that combining automated and hand-held breast ultrasound offers superior diagnostic specificity and a higher area under the curve compared to MRI for evaluating high-risk non-mass lesions, effectively reducing unnecessary biopsies while identifying key sonographic features predictive of malignancy.

Xiaobing Chen, Yuxuan Qiu, Xiaojing Xu, Bei Lin, Kaiyan Lou, Hongmei Ran, He Li, Lingyun Bao2026-06-28
📄 medicine

Dynamic Lactate Trajectories Identify Nonlinear Mortality Thresholds and D istinct Risk Phenotypes in Sepsis

This study demonstrates that analyzing dynamic 48-hour lactate trajectories in critically ill sepsis patients reveals distinct risk phenotypes and identifies a nonlinear mortality threshold at approximately 32.5% 24-hour lactate clearance, offering superior prognostic discrimination compared to static measurements and conventional severity scores.

Ying Fu, Zhanzhi Long, Fangyuan Du, Jun Shen, Chun Pan2026-06-28
📄 medicine

Suction mini-PCNL versus standard PCNL for 2–4 cm renal stones: doubly robust comparative effectiveness and treatment-effect heterogeneity

In a prospective cohort of 900 patients with 2–4 cm renal stones, 18Fr suction mini-PCNL demonstrated comparable stone-free rates to standard PCNL while offering superior recovery outcomes (less pain, less bleeding, shorter stay, and lower fever), leading the authors to recommend it as a reasonable default option over individualized selection based on preoperative characteristics.

Yan Yang, Wen Zhong2026-06-28
📄 medicine

Giant Retroperitoneal Ganglioneuroma Successfully Resected with Preservation of the Kidney and Major Vessels: A Case Report

This case report describes the successful surgical resection of an exceptionally large (29.5 cm) retroperitoneal ganglioneuroma in a young man, highlighting the diagnostic challenges posed by its non-specific presentation and the feasibility of preserving vital organs despite the tumor's massive size.

Mohamad Alharbi, Ahmad Alabdlilrazzak, Abd Albadee Abd Alkareem, Mohammad Noor Katranjy, Samer Muhsen2026-06-28
📄 medicine

Primary Care Physicians’ Perspectives on Video Consultation Services for acute medical conditions in public primary care clinics in Singapore: A Qualitative Study

This qualitative study of 16 primary care physicians in Singapore reveals that while they find video consultations for acute conditions convenient and acceptable, they face significant challenges regarding platform usability, increased administrative burdens, and safety concerns for elderly or complex patients lacking physical examinations.

Jambay Dorji, Stella Xiao Jun Poh, Emily Pui-Yan Lee, Gary Chun-Yun Kang, Aminath Shiwaza Moosa, Ngiap Chuan Tan2026-06-28
📄 medicine

Diagnostic Value of Combined Automated Breast Ultrasound System and Conventional Two-Dimensional Ultrasound for Intraductal Breast Lesions

This study demonstrates that combining Automated Breast Ultrasound System (ABUS) with conventional two-dimensional ultrasound significantly improves the preoperative differentiation of benign and malignant intraductal breast lesions, achieving a diagnostic accuracy (AUC of 0.90) superior to either modality used alone.

Qiuya Yang, Ran Yi, Feiyue Guo, Taohua Gou, Lei Cai, Shuo Wang, Yan Zhang, Yukun Luo2026-06-28
📄 medicine

Exploring Value-Creating Contexts in the Capacity Building of Nursing Managers: A Reflective Thematic Analysis

This qualitative study of 26 nursing managers in Iran identifies that capacity building is shaped by a value-creating context comprising family experiences, community developmental factors, and organizational conditions, suggesting that healthcare organizations should integrate these contextual influences into leadership development programs.

Mohammad Azim Mahmodi, Hossein Sadeghnezhad, ayob akbari2026-06-28
📄 medicine

Triglyceride-Glucose Index Adjusted for Body Mass Index and Risk of MASLD: Evidence from a Cross-Sectional Study

This cross-sectional study of 16,844 U.S. adults demonstrates that the combined Triglyceride-Glucose Index and Weight-Adjusted Waist Index (TyG-WWI) is a superior predictor of metabolic dysfunction-associated steatotic liver disease (MASLD) risk compared to either indicator alone, particularly among individuals with a lower BMI.

Jin’e Li, Jiajun Qiu, Tiantian Cui, Shan Xu, Ziwei Zeng, Yuying Zhang, Shiqi Yang, Jianping Liu2026-06-28