📄 Category

medicine

6877 papers

📄 medicine

Have we gotten better at diagnosing PDAC before it is too late?: Temporal Trends in Stage at Diagnosis of Pancreatic Ductal Adenocarcinoma in the United States

A retrospective analysis of US SEER data from 2004 to 2022 reveals a significant temporal shift toward earlier-stage diagnosis of pancreatic ductal adenocarcinoma, particularly for localized disease, likely driven by improved imaging and screening efforts, though further research is needed to confirm if this translates to improved survival.

Dina Hauptschein, Paul Kang, Surabhi Amar2026-06-28
📄 medicine

The Influence of Eye-Lip Interaction on Facial Attractiveness and Orthodontic Treatment Willingness: A Cross-Sectional Study

This cross-sectional study demonstrates that larger eyes significantly increase observers' tolerance for lip protrusion and reduce the perceived necessity for orthodontic treatment, with laypersons showing greater sensitivity to this eye-lip interaction than dental professionals.

Baodong Hao, Mingjin Zhang, Liang Lyu, Tingting Yu, Jiajing Li, Runzhi Guo, Dawei Liu2026-06-28
📄 medicine

Current status and influencing factors of online health information seeking behavior in elderly stroke patients based on latent profile analysis: a cross-sectional study

This cross-sectional study of 327 elderly stroke patients utilized latent profile analysis to identify three distinct subtypes of online health information-seeking behavior and determined that age, education, income, eHealth literacy, patient activation, social support, and self-efficacy are significant predictors of these behavioral patterns.

Jiale Wang, Yaqi Pang, ning Jin, Shuliang Chen2026-06-28
📄 medicine

Whole-genome Sequencing of Reed-sternberg Cells Identifies Outcome Determinants in Hodgkin Lymphoma

This study utilized whole-genome sequencing of purified Hodgkin and Reed–Sternberg cells from 76 patients to identify specific somatic copy number variations and mutational signatures linked to clinical outcomes, ultimately developing the TRACER-HL model to effectively stratify relapse risk in classical Hodgkin lymphoma.

Jesús Velasco-Suelto, Laura Gálvez-Carvajal, Esperanza López-López, Antonio Cantarero-Cuenca, Silvia Sequero-López, Nati (…)2026-06-28
📄 medicine

How to Translate Early Detection of NAFLD in Cardiovascular-Kidney-Metabolic Syndrome: A Machine-Learning Model Integrating the Atherogenic Index of Plasma

This study demonstrates that an interpretable meta-analytical multi-task learning model utilizing the dynamic atherogenic index of plasma (AIP) outperforms traditional methods in predicting early cardiovascular-kidney-metabolic syndrome transitions in patients with NAFLD, establishing AIP as a superior predictive biomarker for proactive clinical risk interception.

Jinyu Wang, Ziying Jiang, Yifeng Ding, Tongle Yin, Miao Zheng, Rucheng Chen, Weijun Zheng, Hui Kan2026-06-28
📄 medicine

Real-world implementation of a ventilation feedback device during out-of-hospital cardiac arrest: a population-based observational study from a French prehospital system

This population-based observational study from a French prehospital system reveals a significant gap between protocol and real-world usage of ventilation feedback devices during out-of-hospital cardiac arrest, with only 28.9% utilization despite a mandate, while exploratory data suggest potential clinical benefits that warrant further investigation with robust implementation strategies.

Jean-Baptiste Pretalli, Marie Da Cunha, Saïd Hachimi-Idrissi, Laure-Estelle Piller, Abdo Khoury2026-06-28
📄 medicine

Epileptic Seizures at Presentation in Surgically Resected NSCLC Brain Metastases: Prevalence, Predictors, and Prognostic Significance

In a retrospective study of 299 patients with surgically resected NSCLC brain metastases, seizures at presentation occurred in 25.1% of cases and were independently predicted by younger age, immunotherapy use, and absence of intracranial pressure symptoms, yet while seizure occurrence alone did not impact overall survival, a composite score incorporating seizure status along with age, tumor count, and immunotherapy use successfully stratified patients into distinct survival tiers.

András Piffkó, Benedikt Asey, Cécile Maire, Jakob Matschke, Krystian Fita, Katrin Lamszus, Lasse Dührsen, Thomas Sauvign (…)2026-06-28
📄 medicine

Early-Stage Primary Ovarian Insular Carcinoid in a Young Infertile Woman Managed With Fertility Preservation: A Rare Case Report

This case report describes the successful fertility-sparing management of a rare primary ovarian insular carcinoid tumor arising within a mature cystic teratoma in a 30-year-old infertile woman, demonstrating that careful staging and individualized treatment can yield excellent oncologic outcomes while preserving reproductive potential.

Maryam Mohammadzadeh, Hamidreza Mansour, Akram Ghahghaei-Nezamabadi, Ladan Kashani, Afsaneh Tehranian, Mona Alaeii, Mahd (…)2026-06-28
📄 medicine

Mapping the need for specialized pediatric palliative care in Luxembourg: A first retrospective hospital study and survey among parents and pediatricians

This mixed-method study in Luxembourg identifies a significant population of children with complex, life-limiting conditions who experience high healthcare utilization and unmet needs, demonstrating strong support from both families and pediatricians for establishing a specialized pediatric palliative care service to improve coordination, advance care planning, and reduce avoidable hospitalizations.

Isabelle Kieffer, Marie Friedel, Fernand Pauly, Matthias Schell, Cathy Scholtes2026-06-28