6901 papers
This retrospective review demonstrates that intravenous buprenorphine micro-induction is an effective inpatient strategy for transitioning patients using fentanyl to maintenance therapy, with a 2 mg sublingual start post-IV offering a simplified workflow and reduced dosing burden compared to a 1 mg start without compromising withdrawal improvement.
This randomized controlled trial demonstrates that a Jigsaw-based cooperative learning intervention significantly outperforms traditional lecture-based instruction in enhancing clinical reasoning, diagnostic accuracy, communication skills, and knowledge retention among undergraduate dental students in pediatric dentistry.
This retrospective cohort study utilizing the MIMIC-IV database reveals that higher admission serum phosphate levels are an independent, non-linear predictor of increased 30-day and 90-day mortality in adult cardiac arrest patients, demonstrating moderate predictive performance comparable to the SOFA score.
This case-control study demonstrates that serum FGF2 levels are significantly elevated in patients with ocular tumors compared to healthy controls and are even higher in malignant cases, suggesting FGF2's potential as a biomarker for both the diagnosis and differentiation of ocular tumors.
This 2023 study analyzing India's Medical Certification of Cause of Death data reveals that congenital anomalies, particularly circulatory system defects, remain a leading cause of child mortality with higher rates in males and surprisingly higher odds in states with better child health indicators, underscoring the urgent need for early detection, targeted treatment of heart defects, and strengthened civil registration systems.
This cross-sectional study conducted in Western India from 2024 to 2025 analyzed 6,068 extrapulmonary tuberculosis samples and found a 16.43% molecular positivity rate with a 6.11% drug resistance prevalence dominated by rifampicin resistance, underscoring the critical need for universal drug susceptibility testing and enhanced surveillance.
This study developed and validated a noninvasive AI model integrating DCE-MRI and clinicopathologic features that outperforms traditional methods in predicting recurrence risk and personalizing treatment for early-stage HR+/HER2− breast cancer.
This case report describes a 7-year-old girl with a novel homozygous HSD3B7 frameshift variant who presented with a rare, late-onset, malabsorption-dominant phenotype of congenital bile acid synthesis disorder type 1 accompanied by renal microcysts, highlighting the critical need to consider urinary bile acid analysis in children with unexplained malabsorption regardless of neonatal history to enable early, disease-modifying treatment.
This cross-sectional study in Dara Malo district, Southern Ethiopia, found a household-level prevalence of 5.11% for parasitologically confirmed cutaneous leishmaniasis and identified significant deficiencies in community knowledge, attitudes, and preventive practices, particularly among males, those with lower education and income, and farming households.
In a cross-sectional analysis of the Rakai Community Cohort Study in Uganda, HIV serostatus was not found to be significantly associated with diagnosed diabetes, whereas older age, higher BMI, higher socioeconomic status, and residence in a fishing community were identified as significant independent risk factors.