13473 papers
This retrospective cohort study found that administering prophylactic antibiotics at the time of history- or ultrasound-indicated transvaginal cerclage placement does not improve gestational age at delivery or enhance maternal and neonatal outcomes compared to no antibiotic use.
From a Chinese healthcare perspective, a cost-effectiveness analysis based on the HARMONi-6 trial indicates that first-line treatment with ivonescimab plus chemotherapy is likely to be cost-effective compared to tislelizumab plus chemotherapy for advanced squamous non-small cell lung cancer, with an incremental cost-effectiveness ratio of $23,366.05 per quality-adjusted life-year gained.
This study elucidates that high-level ceftazidime-avibactam resistance in carbapenem-resistant *Pseudomonas aeruginosa* is primarily driven by metallo-β-lactamase production (specifically AFM-1 and IMP-45), novel GES variants, and synergistic efflux pump overexpression, contributing to a high mortality rate of 68.1% among critically ill patients.
This case report describes a rare instance of an oral foregut duplication cyst in a 6-year-old boy that mimicked ankyloglossia, highlighting the importance of considering this congenital anomaly in the differential diagnosis of midline tongue masses and confirming that complete surgical excision is curative.
This study successfully developed and preliminarily validated a seven-domain, 46-item Entrustable Professional Activities (EPA) evaluation indicator system for undergraduate nursing interns in rehabilitation, demonstrating strong expert consensus and clinical feasibility to inform future rehabilitation nursing education.
This prospective mixed-methods study demonstrates that the low-cost, prepackaged S-Condom Uterine Balloon Tamponade is a highly feasible, safe, and acceptable intervention for managing refractory atraumatic postpartum hemorrhage in Bangladesh, achieving a 100% success rate and high provider and patient satisfaction.
This case report demonstrates that off-label bromelain-based enzymatic debridement is a safe and effective tissue-sparing strategy for managing complex postoperative wound dehiscence in a preterm newborn, leading to rapid wound closure without adverse events.
This study reveals that while hemodialysis patients exhibit distinct NK cell dysfunction compared to healthy aging, their reduced cytotoxicity is specifically associated with hypoalbuminemia, suggesting malnutrition as a key contributing factor.
This pharmacovigilance study analyzing over 40,000 FAERS reports identifies robust safety signals linking anti-neoplastic drugs, particularly immune checkpoint inhibitors like pembrolizumab and ipilimumab, to endocrine toxicity, highlighting a higher prevalence in females and a tendency for early onset to underscore the need for enhanced clinical monitoring.
This qualitative institutional analysis of Health Policy and Systems Research (HPSR) in Cambodia identifies critical supply and demand constraints, including limited local capacity, low domestic demand for evidence, and donor dominance, which collectively hinder the generation of contextually relevant, evidence-informed health policies and underscore the urgent need for strengthened local ownership and resource allocation to ensure sustainable system learning.