3171 papers
This study characterizes the molecular profiles and antimicrobial resistance patterns of uropathogenic bacteria isolated from elderly nursing home residents in Accra, Ghana, revealing a high prevalence of multidrug-resistant Gram-negative pathogens, particularly *E. coli* and *K. pneumoniae*, carrying diverse virulence and ESBL genes.
This mixed-method retrospective study demonstrates that the establishment of Nigeria's National Emergency Routine Immunization Coordination Center (NERICC) significantly improved routine immunization coverage, evidenced by a 51% increase in average Penta3 coverage across prioritized states between 2016 and 2021, highlighting the critical role of coordinated, evidence-based interventions in strengthening health systems.
This prospective study of 5,452 Chinese adults demonstrates that the concurrent presence of rapid kidney function decline and increasing depressive symptoms exerts a significant synergistic effect on the risk of new-onset stroke, highlighting the value of dynamic monitoring of both renal and psychological trajectories for improved stroke prevention.
This cross-sectional analysis of HINTS 7 data reveals that while current ENDS use, female gender, younger age, and high trust in scientists and family members are associated with the belief that ENDS aid smoking cessation, this belief does not significantly motivate quitting intentions among current combustible cigarette smokers.
This study elucidates the molecular basis for the Traditional Chinese Medicine principle of "same treatment for different diseases" in ovarian, cervical, and bladder cancers by demonstrating that liver-kidney meridian-associated herbal compounds, particularly β-sitosterol and quercetin, converge on shared hub targets (AKT1, MYC, TP53, EGF, MMP9) and the PI3K-Akt pathway to regulate tumor progression and drug resistance.
This retrospective cohort study of children undergoing elective non-cardiac surgery in China found that while preoperative upper respiratory tract infection symptoms were associated with increased emergence respiratory adverse events and longer PACU stays in the post-COVID-19 era, these risks were not significantly elevated in the pre-pandera period, suggesting that the impact of URTI on perioperative outcomes is modulated by the temporal context of the pandemic.
This study demonstrates that a synergistic triple-combination of thiol-reactive reagents (acrylamide, auranofin, and buthionine sulfoximine) effectively induces lethal oxidative stress and cell death in glioblastoma cells by disrupting redox signaling pathways while sparing primary neuronal cultures, offering a promising therapeutic strategy for treating glioblastoma.
This retrospective cohort study developed and externally validated a laboratory-free, nurse-assessable sepsis prediction model using XGBoost that demonstrated strong internal performance but poor external generalizability, suggesting that a simplified five-variable version may offer better cross-institutional transportability for emergency department triage despite requiring further prospective validation.
This cross-sectional study of Cameroonian healthcare workers reveals a high prevalence of musculoskeletal disorders, particularly in the lower back and neck, which are significantly associated with factors such as age, occupation, sedentary behavior, and poor physical health-related quality of life, while moderate physical activity serves as a protective factor.
This study establishes a rapid, scalable, and GMP-compatible 10-day manufacturing platform that generates highly specific, polyfunctional, and allogeneic virus-specific T cells with tissue-homing features and resident-memory-like plasticity, effectively overcoming precursor frequency limitations for treating refractory viral infections.