13473 papers
By integrating bulk and single-cell transcriptomic data with machine learning algorithms, this study identifies ABCD1 as a robust diagnostic and prognostic biomarker that is highly expressed in malignant melanoma cells and correlates with poor patient survival and advanced disease stages.
This 2025 mixed-methods study in Guinea reveals a paradox where health stakeholders hold positive attitudes toward evidence-informed decision-making yet face significant structural barriers, such as poor communication channels and misaligned incentives, which severely limit the actual translation of research into health policy and practice.
This study presents an interpretable concept-bottleneck vision-language model that predicts pathologic complete response in breast cancer patients using longitudinal DCE-MRI data by routing predictions through radiologist-recognizable imaging concepts, thereby achieving generalizable performance while transforming a black-box task into a transparent and auditable clinical tool.
This prospective study of 200 pregnant women in New Delhi found that the second-trimester quadruple test demonstrates moderate predictive ability for preterm birth, outperforming its individual biomarker components with an AUC of 0.747 and a negative predictive value of 89.5%.
This case report describes a patient with chronic drug-induced liver injury exhibiting autoimmune-like features who achieved biochemical remission and histological improvement over time, highlighting the importance of long-term follow-up and repeat liver biopsies to assess persistent histological damage even after biochemical normalization.
Although the prevalence of pit and fissure sealants among 12-year-old children in Puerto Rico significantly increased between 1997 and 2011 following the implementation of Government Health Insurance, a persistent socioeconomic disparity remained, with children in public schools having lower sealant rates than those in private schools.
This study suggests that while exercise-induced systolic pulmonary arterial pressure does not significantly differ between hereditary hemorrhagic telangiectasia patients with high versus normal cardiac output, the steeper systolic pressure-to-cardiac output slope in high-output patients may serve as an early marker for cardiovascular impairment and future pulmonary hypertension risk.
This study demonstrates that a locked two-pathway transcriptomic score for early mortality in diffuse large B-cell lymphoma retains a reproducible association across independent cohorts primarily through an immune-depletion signal, though it currently lacks the calibration required for clinical predictor or treatment threshold use.
In a seven-year study of older Chinese adults, frailty alone or combined with sarcopenia significantly increased the risk of falls and hip fractures compared to neither condition, whereas sarcopenia alone showed no clear association and the coexistence of both conditions did not confer excess risk beyond their individual effects.
Despite good knowledge and favorable attitudes, adverse drug reaction reporting among healthcare professionals in private health facilities in Mbarara City, Uganda, remains critically low (12.9%) due to systemic barriers such as the unavailability of reporting tools, lack of feedback, and insufficient training, highlighting an urgent need to strengthen pharmacovigilance infrastructure in the private sector.