📄 Category

medicine

3171 papers

📄 medicine

Impact of different physical examination frequencies on biochemical indicator variability in community-dwelling older adults: an 8-year retrospective cohort study

This 8-year retrospective cohort study of over 57,000 older adults in Shanghai reveals that while higher frequencies of health examinations are significantly associated with improved long-term trajectories for renal and hepatic function and LDL cholesterol, they are paradoxically linked to faster increases in BMI and triglycerides, suggesting that regular monitoring must be integrated with lifestyle interventions for comprehensive health promotion.

Haiyang Zhang, pei Lian, Tingting Wu, Peiyu Xu, Ting Zhou, Junying Yu, Hongkai Tao, Hong Yu2026-07-14
📄 medicine

Post-discharge survival and incomplete postnatal care continuum among newborns discharged from hospital-based newborn care in Ethiopia: a prospective cohort study

This prospective cohort study of 896 newborns in Ethiopia found that while post-discharge survival rates were high, the completion of the full postnatal care continuum remained low, with key predictors for care utilization including longer facility stays, maternal awareness of danger signs, and knowledge of follow-up timing.

Alula M Teklu, Wendemaghen Gezahegn, Wondimye Ashenafi, Eskinder Wolka, Tilahun Haregu, James A. Litch2026-07-14
📄 medicine

KIF24 depletion induces Fe–S-dependent mitochondrial dysfunction and AMPK/p53/SLC7A11 mediated ferroptosis in gastric cancer

This study identifies KIF24 as a critical oncogenic factor in gastric cancer that confers resistance to ferroptosis by maintaining Fe–S-dependent mitochondrial function, and demonstrates that its depletion triggers cell death via the AMPK/p53/SLC7A11 signaling axis, highlighting KIF24 as a promising therapeutic target.

Ji-Bin Liu, Hai-Xia Zhu, Chun-Yan Gu, Qi ying Yu, Jing-Jing Shao, Li Song, Yu Wu2026-07-14
📄 medicine

Reversible Optic Nerve Conduction Recovery After Teprotumumab in Dysthyroid Optic Neuropathy: Longitudinal Visual Evoked Potential Findings

This case report demonstrates that teprotumumab therapy in a patient with dysthyroid optic neuropathy led to significant clinical and electrophysiologic recovery, evidenced by the normalization of visual acuity and the reversal of delayed visual evoked potential latencies, supporting serial VEP assessment as an objective biomarker for treatment response.

Mizuki Tagami, Taichi Higashida, Gen Kinari, Yusuke Haruna, Shigeru Honda2026-07-14
📄 medicine

Development and Internal Validation of a Nomogram for Predicting 28-Day Mortality in Elderly Hip Fracture Patients Admitted to the Intensive Care Unit: A Retrospective Cohort Study Based on MIMIC-IV

This retrospective cohort study utilizing the MIMIC-IV database developed and internally validated a nomogram incorporating initial hyperlactatemia, age, blood urea nitrogen, and the paradoxical protective effect of diabetes to predict 28-day mortality in elderly hip fracture patients admitted to the ICU.

Yifeng Zhao, Jinxuan Li, Xiaoping Cui2026-07-14
📄 medicine

Integrating value-based reflection into the 7E teaching model in nursing rounds: Effects on nursing students’empathy, moral sensitivity, humanistic care, and patient safety—A quasi-experimental study

This quasi-experimental study demonstrates that integrating value-based reflection into the 7E teaching model for nursing rounds significantly enhances nursing students' empathy, moral sensitivity, humanistic care, and patient safety competence compared to traditional instruction.

Na Zhang, Xue Zhang, Chenlin Yu, Hanyu Li, Shaoli Zhang, Junfan Zhou, Minling Mo2026-07-14
📄 medicine

Diagnostic Performance of Clinical, Biochemical and Ultrasonographic Parameters in Differentiating Biliary Atresia from Idiopathic Neonatal Hepatitis: A Prospective Study from a Tertiary Care Center of Nepal

This prospective study from a Nepalese tertiary center demonstrates that a cost-effective diagnostic strategy combining persistent acholic stool, a serum GGT cutoff of ≥384.5 U/L, and ultrasonography can effectively differentiate biliary atresia from idiopathic neonatal hepatitis, offering a high-sensitivity parallel screening approach followed by a high-specificity serial confirmation for resource-limited settings.

Saroj Kumar Sah, Raj Kumar Nepal, Sumit Agrawal, Santosh Adhikari, Lisha Yadav, Baburam Pandey, Ram Hari Chapagain2026-07-14
📄 medicine

Development and validation of a 17-year risk prediction nomogram for metabolic syndrome: a retrospective cohort study

This retrospective cohort study developed and validated a robust 17-year risk prediction nomogram for metabolic syndrome using 11 key clinical factors, demonstrating high accuracy and clinical utility for early identification and intervention in a large population-based sample.

Lei Yu, Kexin Zhao, Zhendong Hu, Weihong Zhou, Minhua Luo, Pengfei Zhang, Tiancheng Xu2026-07-14
📄 medicine

Dynamic Patterns of Estimated Cardiorespiratory Fitness and Risk of Depressive Symptoms in Older Adults: A Longitudinal Analysis Using LTMLE

Using longitudinal data from 7,109 older adults and advanced causal inference methods, this study demonstrates that maintaining high estimated cardiorespiratory fitness over time significantly and independently reduces the risk of depressive symptoms, whereas rapid declines in fitness eliminate these protective benefits.

Jingyi Li, Yaning Feng2026-07-14