6901 papers
This retrospective study of 281 patients with endogenous Cushing syndrome reveals distinct age-dependent phenotypes, where pediatric cases are characterized primarily by growth failure and pubertal disturbances, while adult presentations are dominated by a higher cumulative burden of cardiometabolic, myopathic, and skeletal complications.
This study validates the HC3A250 wearable monitor as a reliable tool for detecting post-stroke paroxysmal atrial fibrillation compared to standard 12-lead ECG, though it found no statistically significant association between mechanical thrombectomy and new-onset atrial fibrillation after adjusting for confounders.
This study demonstrates that bilateral implantation of the hydrophilic Synthesis Plus EDOF intraocular lens yields stable long-term refractive results and excellent distance and intermediate visual acuity over a three-year follow-up period.
This cross-sectional study of 123 older adults with chronic diseases reveals that intentional medication non-adherence is significantly predicted by economic sufficiency and specific attitudes toward death, highlighting the critical role of psychosocial and existential factors in shaping treatment decisions.
This study developed and validated a multiparametric nomogram integrating 18F-FDG PET/CT metabolic parameters, CT imaging features, and the lymphocyte-to-monocyte ratio to accurately predict the presence of spread through air spaces (STAS) in patients with clinical stage IA lung adenocarcinoma, thereby aiding preoperative risk stratification and surgical decision-making.
By integrating X-ray micro-CT and Raman spectroscopy, this study reveals that calcium oxalate kidney stones possess a complex hierarchical microarchitecture defined by concentric mineral layers intergrown with microbial biofilms, challenging traditional precipitation models and highlighting biofilms as fundamental structural determinants.
This study demonstrates that cefiderocol exhibits potent in vitro activity against 97.4% of multidrug-resistant Gram-negative isolates collected in Niger, supporting its potential as a last-line therapeutic option despite rare resistance cases linked primarily to NDM-1 producers.
This study utilized uncontrolled manifold analysis on a gait dataset of 53 hip osteoarthritis patients to demonstrate that while total hip arthroplasty alters specific coordination variances, the body maintains stable center-of-mass control by flexibly exploiting available degrees of freedom, suggesting that postoperative rehabilitation should prioritize whole-movement system coordination over isolated joint function.
This study demonstrates that liraglutide alleviates hepatic lipid accumulation in hepatocytes by activating the SIRT1/PGC-1α/PPARα signaling pathway to promote fatty acid β-oxidation, identifying SIRT1 as a key therapeutic target for metabolic-associated fatty liver disease.
This retrospective study of 318 acute ischemic stroke patients reveals that higher non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratios (NHHR) are significantly associated with an increased prevalence of hyperuricemia, particularly among non-smokers and non-diabetic individuals.