6901 papers
This case report describes a critically ill patient with severe fluid overload who experienced life-threatening rebound methotrexate toxicity five weeks after apparent clearance, illustrating how altered pharmacokinetics and drug sequestration in dynamic volume-overload states can render standard clearance thresholds unreliable.
This qualitative study reveals that low NHS Health Check uptake among Black Caribbean, Ghanaian, and Nigerian communities in Birmingham stems from distinct, community-specific structural and cultural barriers—including unfamiliarity, racialized gatekeeping, and culturally irrelevant protocols—necessitating disaggregated, co-designed interventions rather than a homogenized "pan-Black" approach.
This phase II study demonstrates that combining the PCSK9 inhibitor alirocumab with cemiplimab yields clinical activity in immunorefractory NSCLC patients, with significantly improved response rates specifically observed in those harboring PIK3CA, PTEN, or AKT1 alterations.
This study demonstrates that optimizing probability thresholds significantly enhances the clinical utility of COVID-19 mortality prediction models by improving specificity and balanced accuracy, while showing that interpretable logistic regression performs comparably to more complex machine learning algorithms.
This study developed and validated a multimodal deep learning-radiomics-clinical model using dual-phase contrast-enhanced CT scans and clinical data to accurately predict acute lung injury in patients with acute pancreatitis, demonstrating superior performance over unimodal approaches across training, internal, and external test sets.
A stochastic modeling study demonstrates that implementing the rapid 7-1-7 outbreak response framework in Uganda during a Bundibugyo Ebola virus cross-border outbreak would be strictly dominant, significantly reducing both cases and deaths while saving costs compared to a delayed response scenario.
This study demonstrates that male BALB/cJ mice develop severe radiation-induced heart failure with reduced ejection fraction, inflammation, and fibrosis, whereas females exhibit a milder phenotype characterized by preserved ejection fraction and enhanced mitochondrial repair, highlighting significant sex differences in the pathogenesis of radiation-induced cardiotoxicity.
This study introduces the Hierarchical Bayesian Multimodal Attention Fusion Network (HBMAF-Net), a novel framework that effectively integrates clinical, genomic, and imaging data to deliver accurate, interpretable, and uncertainty-aware personalized cancer prognosis, outperforming conventional and state-of-the-art models in predictive performance and calibration.
This explanatory sequential mixed-methods study reveals that onchocerciasis in Bo District, Sierra Leone, imposes a near-universal, multidimensional socio-economic and psychological burden that is uniformly distributed across the community rather than concentrated in specific demographic groups, necessitating population-wide rather than targeted intervention strategies.
This nationwide longitudinal study in Brazil found that in-utero exposure to Chikungunya is associated with persistently higher weight-for-length and BMI z-scores, significantly increasing the risk of obesity in children during their first five years of life.