6901 papers
This phase I clinical study demonstrates that early postoperative microbiota transplant therapy is safe, feasible, and associated with coordinated recovery dynamics across microbial, metabolic, and immune systems in patients undergoing colorectal surgery.
This mixed-methods study demonstrates that person-centered maternity care significantly influences Black women's subsequent pregnancy and birthing intentions, with those experiencing poor care reporting drastically higher odds of altering their future birth settings or avoiding childbirth due to mistreatment and a loss of trust in the health system.
This community-based cross-sectional study in Ndola District, Zambia, reveals a high prevalence of coexisting behavioural risk factors—including alcohol consumption, smoking, physical inactivity, and poor diet—among adults, underscoring the urgent need for targeted interventions to mitigate the rising burden of non-communicable diseases.
This randomized controlled trial found that while a 12-week combination of sensory integration and Schroth therapy significantly improved vital capacity and directly enhanced quality of life in adolescents with mild idiopathic scoliosis, these specific physiological improvements did not statistically mediate the observed gains in quality of life, suggesting the therapy's mechanism involves more complex, unmeasured pathways.
Using data from the China Health and Retirement Longitudinal Study, this study reveals that higher aggressive urbanization is independently associated with lower odds of dyslipidemia but increased all-cause mortality among middle-aged and older Chinese adults, exhibiting significant nonlinear patterns and subgroup heterogeneity.
This case report describes a rare instance of a 15-year-old female basketball player developing polyarticular juvenile idiopathic arthritis three weeks after anterior cruciate ligament reconstruction, which was successfully treated with methotrexate and tocilizumab, ultimately allowing her to return to competitive sports without residual symptoms.
This study demonstrates that primary tumors and matched lymph node metastases in differentiated thyroid carcinoma exhibit high, time-independent molecular concordance, supporting the clinical utility of using primary tumor-only genetic testing to guide management and reduce redundant testing costs.
This preliminary retrospective study found that while the first-trimester nuchal translucency-to-maxillary length ratio is significantly elevated in fetuses with trisomy 21 and shows good discriminatory performance, it is not statistically superior to nuchal translucency measurement alone, necessitating larger prospective studies before clinical adoption.
This study of over 25,000 women in the Women's Health Initiative reveals that a history of adverse pregnancy outcomes, particularly hypertensive disorders of pregnancy, is independently associated with an increased risk of developing chronic obstructive pulmonary disease later in life, suggesting that abnormal pregnancy may serve as an early indicator of long-term respiratory vulnerability.
This 12-month real-world study demonstrates that weekly treatment with semaglutide or tirzepatide significantly reduces APRI and FIB-4 scores in adults with obesity, suggesting that these incretin-based therapies may offer benefits beyond weight loss by potentially lowering the risk of liver fibrosis.